Sandaracopimaric acid

Cat. No.: HY-133594 Purity: 98.86%: FAQs
Data Sheet SDS COA Handling Instructions

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Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC₅₀ of 43.93 μM.

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Sandaracopimaric acid Chemical Structure

CAS No. : 471-74-9

Size	Price	Stock	Quantity
1 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC₅₀ of 43.93 μM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 40 μM Compound: 11	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23691952]
HL-60	IC₅₀	> 40 μM Compound: 11	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23691952]
MCF7	IC₅₀	> 40 μM Compound: 11	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23691952]
Oocyte	EC₅₀	24.9 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis	[PMID: 21793559]
Oocyte	EC₅₀	31.2 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis	[PMID: 21793559]
Oocyte	EC₅₀	33.3 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis	[PMID: 21793559]
Oocyte	EC₅₀	40.7 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis relative to control Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis relative to control	[PMID: 21793559]
Oocyte	EC₅₀	48.1 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis	[PMID: 21793559]
Oocyte	EC₅₀	56.6 μM Compound: 5	Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis	[PMID: 21793559]
SMMC-7721	IC₅₀	> 40 μM Compound: 11	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 23691952]
SW480	IC₅₀	> 40 μM Compound: 11	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23691952]

Molecular Weight

302.45

Formula

C₂₀H₃₀O₂

CAS No.

471-74-9

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]1(C)CCC[C@]2(C)[C@@]3([H])CC[C@](C)(C=C)C=C3CC[C@@]12[H])O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 3.5 mg/mL (11.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3063 mL	16.5317 mL	33.0633 mL
5 mM	0.6613 mL	3.3063 mL	6.6127 mL
10 mM	0.3306 mL	1.6532 mL	3.3063 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (250 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)

References

[1]. Wenyan Gao, et al. Dehydroabietic acid isolated from Commiphora opobalsamum causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Molecules. 2014 Jun 23;19(6):8503-17. [Content Brief]

[2]. Masao Takei, et al. Diterpenes drive Th1 polarization depending on IL-12. Int Immunopharmacol. 2008 Nov;8(11):1602-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3063 mL	16.5317 mL	33.0633 mL	82.6583 mL
	5 mM	0.6613 mL	3.3063 mL	6.6127 mL	16.5317 mL
	10 mM	0.3306 mL	1.6532 mL	3.3063 mL	8.2658 mL