Sanfetrinem sodium (Synonyms: GV104326 sodium)

Cat. No.: HY-106922A: FAQs
Data Sheet Handling Instructions

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Sanfetrinem (GV104326) sodium is a beta-lactamase-stable antibiotic. Sanfetrinem sodium has broad-spectrum activity against gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Sanfetrinem sodium Chemical Structure

CAS No. : 141611-76-9

Size	Price	Stock
1 mg	USD 370	Ask For Quote & Lead Time
5 mg	USD 928	Ask For Quote & Lead Time
10 mg	USD 1350	Ask For Quote & Lead Time
25 mg	USD 2430	Ask For Quote & Lead Time
50 mg	USD 3520	Ask For Quote & Lead Time
100 mg	USD 5040	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Sanfetrinem sodium:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sanfetrinem (GV104326) sodium is a beta-lactamase-stable antibiotic. Sanfetrinem sodium has broad-spectrum activity against gram-positive and gram-negative bacteria^[1].

IC₅₀ & Target

β-lactam

In Vitro

Sanfetrinem (4 μg/mL) sodium inhibits 99.5% of the strains, including B. fragilisgroup, B. fragilis, B. thetaiotaomicron, B. uniformis^[1].
Sanfetrinem sodium shows potent activity against Staphylococcus aureus with a MIC₉₀ of 0.06 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	B. fragilisgroup, B. fragilis, B. thetaiotaomicron, B. uniformis
Concentration:	0-1 μg/mL approximately
Incubation Time:
Result:	Inhibited bacteria with MIC values of 0.1, 0.1, 0.2, 0.1 μg/mL, recpectively.

Clinical Trial

Molecular Weight

303.29

Formula

C₁₄H₁₈NNaO₅

CAS No.

141611-76-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@H]([C@]1([H])[C@]2([H])N(C(C(O[Na])=O)=C3[C@]2([H])CCC[C@@H]3OC)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (329.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2972 mL	16.4859 mL	32.9717 mL
5 mM	0.6594 mL	3.2972 mL	6.5943 mL
10 mM	0.3297 mL	1.6486 mL	3.2972 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Betriu C, et al. Activities of new antimicrobial agents (trovafloxacin, moxifloxacin, sanfetrinem, and quinupristin-dalfopristin) against Bacteroides fragilis group: comparison with the activities of 14 other agents. Antimicrob Agents Chemother. 1999 Sep;43(9):2320-2. [Content Brief]

[2]. Tamura S, et al. In vivo antibacterial activities of sanfetrinem cilexetil, a new oral tricyclic antibiotic. Antimicrob Agents Chemother. 1998 Jul;42(7):1858-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2972 mL	16.4859 mL	32.9717 mL	82.4294 mL
	5 mM	0.6594 mL	3.2972 mL	6.5943 mL	16.4859 mL
	10 mM	0.3297 mL	1.6486 mL	3.2972 mL	8.2429 mL
	15 mM	0.2198 mL	1.0991 mL	2.1981 mL	5.4953 mL
	20 mM	0.1649 mL	0.8243 mL	1.6486 mL	4.1215 mL
	25 mM	0.1319 mL	0.6594 mL	1.3189 mL	3.2972 mL
	30 mM	0.1099 mL	0.5495 mL	1.0991 mL	2.7476 mL
	40 mM	0.0824 mL	0.4121 mL	0.8243 mL	2.0607 mL
	50 mM	0.0659 mL	0.3297 mL	0.6594 mL	1.6486 mL
	60 mM	0.0550 mL	0.2748 mL	0.5495 mL	1.3738 mL
	80 mM	0.0412 mL	0.2061 mL	0.4121 mL	1.0304 mL
	100 mM	0.0330 mL	0.1649 mL	0.3297 mL	0.8243 mL

Sanfetrinem sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sanfetrinem141611-76-9GV104326GV 104326GV-104326AntibioticBacterialBroad-spectruminfectionStaphylococcus aureusgram-positivegram-negativeInhibitorinhibitorinhibit

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