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1'S-isomers

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Androgen Receptor (1) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (1) CDK (1) Elastase (1) Endogenous Metabolite (2) HMG-CoA Reductase (HMGCR) (2) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) Phosphodiesterase (PDE) (1) Prostaglandin Receptor (1) RSV (1) Thyroid Hormone Receptor (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (4) Endocrinology (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (5)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Drug isomer

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114271A

*T3-ATA (S-isomer)*	Thyroid Hormone Receptor	Endocrinology
T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.

HY-114272A

*T4-ATA (S-isomer)*	Thyroid Hormone Receptor	Endocrinology
T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.

HY-15532B

*SCH900776 (S-isomer)* MK-8776 S-isomer	Others	Cancer
SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC₅₀ of 3 nM.

HY-12993A

RSV604 racemate A-60444 racemate	RSV	Others
RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.

HY-112895A

(R)-UT-155	Androgen Receptor	Cancer
(R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer .

HY-103035

BIO-32546	Phosphodiesterase (PDE)	Cancer
BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1 .

HY-114552

(S)-Dabelotine	Adrenergic Receptor	Neurological Disease
(S)-Dabelotine is the S-isomer of Dabelotine and serves as an adrenergic agonist in the investigation of dementia.

HY-W093104

(S)-(-)-2-Methylbutanol (S)-2-Methyl-1-butanol	Endogenous Metabolite	Others
(S)-(-)-2-Methylbutanol is a S-isomer of 2-Methylbutanol .

HY-19487A

Ribocil B Ribocil S enantiomer; ent-Ribocil A	Bacterial	Infection
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a K_D of 6.6 nM.

HY-167168

(S)-Azelnidipine	Calcium Channel	Cardiovascular Disease
(S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research .

HY-103641A

(2S)-Octyl-α-hydroxyglutarate 2 Publications Verification (2S)-Octyl-2-HG	Others	Cancer
(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.

HY-105109B

(S)-Cilansetron	Others	Neurological Disease
(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome .

HY-129436

(S)-Bucindolol	Adrenergic Receptor	Cardiovascular Disease
(S)-Bucindolol is the (S)-isomer of Bucindolol (HY-103214), a β₁-adrenergic receptor blocker. (S)-Bucindolol can be utilized in research on cardiac failure .

HY-163529A

(S)-HN0037	HSV	Infection
(S)-HN0037 is the (S)-isomer of HN0037 (HY-163529), a selective and orally active helicase-primase inhibitor that inhibits HSV replication by targeting the viral helicase-primase enzyme complex .

HY-126028A

(+)-Sotalol (S)-Sotalol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle .

HY-114061

(R)-FTY 720P	Others	Others
(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P_1,3,4,5 than (S)-Isomer (HY-15382) .

HY-139124

15(R)-15-Methyl Prostaglandin F2α 15(R)-Carboprost; 15(R)-15-methyl PGF2α	Others	Metabolic Disease
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.

HY-75095

(S)-(-)-1-Phenylethanamine S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine	Biochemical Assay Reagents	Neurological Disease
(S)-(-)-1-Phenylethanamine (S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine) is a S-isomer of 1-Phenylethanamine (HY-W012848). 1-Phenylethanamine is a potential central nervous system stimulant and can be used to synthesize the tyrosine kinase inhibitor CLM3 (HY-164413) .

HY-120039A

(S)-MDL-101146	Elastase	Inflammation/Immunology
(S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a K_i value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .

HY-14664F

(3R,5S)-Fluvastatin sodium (3R,5S)-XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy	Cancer
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-111540B

(S)-LY-3381916 1 Publications Verification (S)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-143921S

Almorexant (αS,1S) isomer-13C,d3	Isotope-Labeled Compounds	Others
Almorexant (αS,1S) isomer- ¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant (αS,1S) isomer[1].

HY-112371

(S)-CR8	CDK	Cancer
(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC₅₀s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC₅₀ 0.40 μM) .

HY-121535

Levosemotiadil	Others	Others
Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .

HY-113943

9(S)-HETE	Endogenous Metabolite	Others
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

HY-139121

15(R)-17-Phenyl trinor Prostaglandin F2α 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

HY-101339

(R)-RS 56812	Others	Others
(R)-RS 56812 is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.

HY-101339A

(R)-RS 56812 hydrochloride	Others	Others
(R)-RS 56812 hydrochloride is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.

HY-111156

NW-1172 free base	Monoamine Oxidase	Neurological Disease
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-126031

(R)-KT109	Others	Others
(R)-KT109 is a highly potent inhibitor of diacylglycerol lipase β (DAGLβ) with an IC50 of 0.79 nM and effectively blocks DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol. Additionally, it demonstrates inhibitory activity against α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 of 2.51 nM, exhibiting greater potency for DAGLβ, DAGLα, and ABHD6 compared to its (S) isomer, (S)-KT109.

HY-N7801

(±)5-HEPE	Others	Metabolic Disease
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

HY-117044A

(±)12-HEPE	Others	Metabolic Disease
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

Almorexant (αS,1S) isomer-13C,d3
Almorexant (αS,1S) isomer- ¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant (αS,1S) isomer[1].

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