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Results for "

1,2 diacylglycerol

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

5

Biochemical Assay Reagents

3

Natural
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1

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128468
    1,2-Dimyristoyl-sn-glycerol

    		Liposome PKC Parasite Others
    1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC .
    1,2-Dimyristoyl-sn-glycerol
  • HY-128465
    1,2-Dilauroyl-sn-glycerol

    		Others Others
    1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction .
    1,2-Dilauroyl-sn-glycerol
  • HY-118442
    Sphingosine (d14:1)

    Tetradecasphing-4-enine

    		 PKC Cancer
    Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .
    Sphingosine (d14:1)
  • HY-W127391
    1,2-Dilaurin

    (Rac)-1,2-Didodecanoylglycerol

    		 Biochemical Assay Reagents Others
    1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).
    1,2-Dilaurin
  • HY-165045
    1,2-Dipentadecanoyl-rac-glycerol

    DG(15:0/15:0/0:0); 1,2-Dipentadecanoin

    		 Others Others
    1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound mentioned in the study of the effects of insulin on 1,2-diacylglycerol in rat hearts. Insulin can increase the content of 1,2-diacylglycerol with a specific fatty acid composition in the heart, which may be related to cardiac contractility.
    1,2-Dipentadecanoyl-rac-glycerol
  • HY-115769
    1,2-Didecanoylglycerol

    		PKC Endocrinology
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC) [1] .
    1,2-Didecanoylglycerol
  • HY-117115
    1,2-Dihexanoyl-sn-glycerol

    		Biochemical Assay Reagents Others
    1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.
    1,2-Dihexanoyl-sn-glycerol
  • HY-165056
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol

    1,2-Palmitin-3-linolein; TG(16:0/16:0/18:2)

    		 Others Others
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol (1,2-Palmitin-3-linolein), a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat, was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol
  • HY-165042
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol

    1,2-Palmitin-3-caprin; 1,2-Palmitin-3-decanoin; TG(16:0/16:0/10:0)

    		 Others Others
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol (1,2-Palmitin-3-caprin), a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat, was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol
  • HY-105953
    Froxiprost

    ONO-995

    		 Others Endocrinology
    Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells .
    Froxiprost
  • HY-145541
    12-Dinonadecanoyl-rac-glycerol

    1,2-Dinonadecanoin

    		 Biochemical Assay Reagents Others
    12-Dinonadecanoyl-rac-glycerol is a diacylglycerol containing nonadecanoic acid (HY-W004261) at the sn-1 and sn-2 positions. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence .
    12-Dinonadecanoyl-rac-glycerol
  • HY-117168
    1,2-Dilinoleoyl-sn-glycerol

    		Endogenous Metabolite Metabolic Disease
    1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy.
    1,2-Dilinoleoyl-sn-glycerol
  • HY-P2856
    Phosphatidylinositol phosphodiesterase

    		Endogenous Metabolite Metabolic Disease
    Phosphatidylinositol phosphodiesterase hydrolyzes phosphatidylinositol to diacylglycerols and a mixture of myoinositol 1- and 1, 2-cyclic phosphates .
    Phosphatidylinositol phosphodiesterase
  • HY-W100403
    Choline tosylate

    Choline p-toluenesulfonate

    		 Phospholipase Cancer
    Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) [1] .
    Choline tosylate
  • HY-18551
    DAGLβ-IN-1

    		DAGL Inflammation/Immunology
    DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes [1] .
    DAGLβ-IN-1
  • HY-16278A
    Pradigastat sodium

    LCQ 908 sodium

    		 Acyltransferase Metabolic Disease
    Pradigastat sodium (LCQ-908) is a potent, selective and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor. Pradigastat sodium has anti-obesity and anti-diabetic effects [1] .
    Pradigastat sodium
  • HY-W004260B
    Dieicosanoin

    Glycerol diarachidate

    		 Endogenous Metabolite Biochemical Assay Reagents Others
    Dieicosanoin is a diacylglycerol containing arachidic acid (HY-W004260). Arachidic acid is a saturated long-chain fatty acid with a 20-carbon backbone. Arachidic acid can be isolated from peanut butter and anaerobic fungi [1] .
    Dieicosanoin
  • HY-15497
    AZD7687
    1 Publications Verification

    		 Acyltransferase Metabolic Disease
    AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research [1] .
    AZD7687
  • HY-W010736A
    1,2-Dipalmitoyl-rac-glycerol

    		Biochemical Assay Reagents Others
    1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.
    1,2-Dipalmitoyl-rac-glycerol
  • HY-131897S
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

    		Isotope-Labeled Compounds PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
  • HY-107416
    RHC 80267

    U-57908

    		 DAGL Acyltransferase mAChR COX Phospholipase Neurological Disease Metabolic Disease
    RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) [1] .
    RHC 80267
  • HY-108355
    R59949

    		PKC Cancer
    R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol [1] .
    R59949
  • HY-32219
    T863
    Maximum Cited Publications
    9 Publications Verification

    		 Acyltransferase Metabolic Disease
    T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells [1] .
    T863
  • HY-131897
    1-Stearoyl-2-arachidonoyl-sn-glycerol
    1 Publications Verification

    		 PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity [1] .
    1-Stearoyl-2-arachidonoyl-sn-glycerol
  • HY-115706
    13-Dilignoceroyl glycerol

    1,3-Ditetracosanoin

    		 Biochemical Assay Reagents Neurological Disease
    13-Dilignoceroyl glycerol is a diacylglycerol containing lignoceric acid (HY-121883 ) at the sn-1 and sn-3 positions. Lignoceric acid is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy research [1] .
    13-Dilignoceroyl glycerol
  • HY-107613
    R 59-022
    1 Publications Verification

    DKGI-I; diacylglycerol kinase inhibitor I

    		 PKC 5-HT Receptor Inflammation/Immunology
    R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils [1] .
    R 59-022
  • HY-107613A
    R 59-022 hydrochloride
    1 Publications Verification

    DKGI-I hydrochloride; diacylglycerol kinase inhibitor I hydrochloride

    		 PKC 5-HT Receptor Infection Inflammation/Immunology Cancer
    R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils [1] .
    R 59-022 hydrochloride
  • HY-N9530
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

    		Acyltransferase Angiotensin Receptor Bacterial Infection Cardiovascular Disease Metabolic Disease
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL [1] .
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

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