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Results for "

12(S)-HETE

" in MedChemExpress (MCE) Product Catalog:

4

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1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124404A
    12(S)-HETE

    		ERK DNA/RNA Synthesis p38 MAPK Cancer
    12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .
    12(S)-HETE
  • HY-123023
    12(S)-HETE D8

    		Others Cancer
    12(S)-HETE D8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. 12(S)-HETE D8 is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE D8 is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.
    12(S)-HETE D8
  • HY-142976
    Tetranor-12(S)-HETE

    		Endogenous Metabolite Inflammation/Immunology
    Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis .
    Tetranor-12(S)-HETE
  • HY-117085
    Lobaric acid

    		Others Cancer
    Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50=97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s=15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE by 12(S)-lipoxygenase (IC50=28.5 μM).In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).
    Lobaric acid

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