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Results for "

A427

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163064
    CC-3240

    		Molecular Glues LRRK2 Cancer
    CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC50 of 9 nM .
    CC-3240
  • HY-14151
    Prucalopride
    2 Publications Verification

    		 5-HT Receptor Apoptosis Autophagy Neurological Disease Cancer
    Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
    Prucalopride
  • HY-125905
    VH032-cyclopropane-F
    1 Publications Verification

    VHL ligand 3; E3 ligase Ligand 19

    		 Ligands for E3 Ligase Cancer
    VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4 .
    VH032-cyclopropane-F
  • HY-132295
    Azenosertib
    1 Publications Verification

    ZN-c3

    		 Wee1 Cancer
    Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity .
    Azenosertib
  • HY-106381
    Aurothiomalate sodium

    		PKC Inflammation/Immunology Cancer
    Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity .
    Aurothiomalate sodium
  • HY-168180
    WEE1-IN-11

    		Wee1 Cancer
    WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC50 of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC50s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively .
    WEE1-IN-11
  • HY-P1916
    FliC, Serotype a (427-441), S.paratyphi A

    		Bacterial Infection Inflammation/Immunology
    FliC, Serotype a (427-441), S.paratyphi A is amino acids 427 to 441 fragment belongs to the FliC, serotype a of the S. FliC epitope .
    FliC, Serotype a (427-441), S.paratyphi A
  • HY-P10847
    KS-58

    		Ras Cancer
    KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity .
    KS-58
  • HY-14151R
    Prucalopride (Standard)

    		5-HT Receptor Apoptosis Autophagy Neurological Disease Cancer
    Prucalopride (Standard) is the analytical standard of Prucalopride. This product is intended for research and analytical applications. Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
    Prucalopride (Standard)
  • HY-163697
    WEE1-IN-7

    		Wee1 Apoptosis Cancer
    WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC50 value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity .
    WEE1-IN-7

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