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Results for "

AHPs

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Peptides

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100783
    (-)-Bicuculline methobromide
    Maximum Cited Publications
    21 Publications Verification

    l-Bicuculline methobromide

    		 GABA Receptor Neurological Disease
    (-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca 2+-activated K + channels in various types of neurons .
    (-)-Bicuculline methobromide
  • HY-N0219
    Bicuculline
    Maximum Cited Publications
    21 Publications Verification

    (+)-Bicuculline; d-Bicuculline

    		 GABA Receptor Neurological Disease
    Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca 2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .
    Bicuculline
  • HY-100783A
    (-)-Bicuculline methochloride

    l-Bicuculline methochloride

    		 GABA Receptor Neurological Disease
    (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca 2+-activated K + channels in various types of neurons .
    (-)-Bicuculline methochloride
  • HY-N0219R
    Bicuculline (Standard)

    		GABA Receptor Neurological Disease
    Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .
    Bicuculline (Standard)
  • HY-121914
    (2-Chlorophenyl)diphenylmethanol

    o-Chlorotriphenylmethanol

    		 Calcium Channel Neurological Disease
    (2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC50 for sI(AHP) inhibition is 1-2 μM. (2-chlorophenyl)diphenylmethanol is a weak Ca 2+ channel blocker .
    (2-Chlorophenyl)diphenylmethanol
  • HY-P2033
    Nostopeptin B

    		Elastase Ser/Thr Protease Inflammation/Immunology
    Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against elastase and chymotrypsin .
    Nostopeptin B
  • HY-121914R
    (2-Chlorophenyl)diphenylmethanol (Standard)

    		Calcium Channel Neurological Disease
    (2-Chlorophenyl)diphenylmethanol (Standard) is the analytical standard of (2-Chlorophenyl)diphenylmethanol. This product is intended for research and analytical applications. (2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC50 for sI(AHP) inhibition is 1-2 μM. (2-chlorophenyl)diphenylmethanol is a weak Ca2+ channel blocker .
    (2-Chlorophenyl)diphenylmethanol (Standard)
  • HY-N13115A
    Protoescigenin 21-tiglate

    (E)-21-Angeloyl-protoaescigenin

    		 Others Cancer
    Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .
    Protoescigenin 21-tiglate
  • HY-N13115
    21-Angeloyl-protoaescigenin

    (Z)-Protoescigenin 21-tiglate

    		 Others Cancer
    21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .
    21-Angeloyl-protoaescigenin

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