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Results for "

ALR1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Fluorescent Dye

1

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106697
    Ponalrestat
    1 Publications Verification

    ICI 128436

    		 Aldose Reductase Metabolic Disease
    Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol [1] .
    Ponalrestat
  • HY-121933
    IDD388

    		Aldose Reductase Metabolic Disease
    IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM) [1].
    IDD388
  • HY-122652
    MitoBloCK-6

    		Apoptosis Aldose Reductase Neurological Disease Cancer
    MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia [1] .
    MitoBloCK-6
  • HY-147977
    ALR1/2-IN-1

    		Aldose Reductase Cancer
    ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity [1].
    ALR1/2-IN-1
  • HY-146661
    Aldose reductase-IN-4

    		Aldose Reductase Cancer
    Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC50s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and ALR2, respectively [1].
    Aldose reductase-IN-4
  • HY-151947
    ALR2-IN-3

    		Aldose Reductase Metabolic Disease
    ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 22 nM and 116 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications [1].
    ALR2-IN-3
  • HY-151946
    ALR2-IN-2

    		Aldose Reductase Metabolic Disease
    ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 27 nM and 228 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications [1].
    ALR2-IN-2
  • HY-D0064
    6,7-Dihydroxy-4-coumarinylacetic acid

    		Aldose Reductase Metabolic Disease
    6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation [1].
    6,7-Dihydroxy-4-coumarinylacetic acid

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