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Results for "

ASAH1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bcl-2 Family (1) Ceramidase (2) LPL Receptor (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Acid Ceramidase-IN-1	Ceramidase	Neurological Disease
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC₅₀=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice ^[1].

ASAH1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ASAH1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASAH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ASAH1 Human Pre-designed siRNA Set A ASAH1 Human Pre-designed siRNA Set A

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent *acid ceramidase (ASAH1; AC)* inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models ^[1] .

Cat. No.	Compare	Product Name	Species	Source

	ASAH1 Protein, Human (His-SUMO) AC; ACDase; Acid CDase; Acid ceramidase; Acid ceramidase precursor; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH 1; ASAH; ASAH1; ASAH1_HUMAN; FLJ21558; FLJ22079; N acylsphingosine amidohydrolase (acid ceramidase) 1; N acylsphingosine amidohydrolase 1	Human	E. coli
	ASAH1 is a lysosomal ceramidase that critically regulates sphingolipid metabolism by hydrolyzing ceramide into sphingosine and fatty acids at acidic pH. Bioactive lipids—ceramide, sphingosine, and sphingosine-1-phosphate—control signaling pathways for cell proliferation, apoptosis, and differentiation. ASAH1 Protein, Human (His-SUMO) is the recombinant human-derived ASAH1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of ASAH1 Protein, Human (His-SUMO) is 374 a.a., with molecular weight of ~58.7 kDa.

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ASAH1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ASAH1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASAH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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