ASH

By Targets:	Apoptosis (3) Biochemical Assay Reagents (1) Caspase (1) Endogenous Metabolite (2) Fluorescent Dye (1) Histone Methyltransferase (4) p38 MAPK (3) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (8) Inflammation/Immunology (3) Metabolic Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 µM .

HY-N6990

Anhydrosecoisolariciresinol	Others	Cancer
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-121471

Chrysoeriol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-RS01087

ASH1L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ASH1L Human Pre-designed siRNA Set A contains three designed siRNAs for ASH1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ASH1L Human Pre-designed siRNA Set A ASH1L Human Pre-designed siRNA Set A

HY-RS01088

ASH2L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ASH2L Human Pre-designed siRNA Set A contains three designed siRNAs for ASH2L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ASH2L Human Pre-designed siRNA Set A ASH2L Human Pre-designed siRNA Set A

HY-W111589F

*Kieselguhr, soda ash* flux-calcined**	Biochemical Assay Reagents	Others
Kieselguhr, soda ash flux-calcined is a filter aid.

HY-16521

VX-166	Caspase	Inflammation/Immunology
VX-166, a pan caspase inhibitor, can be used for the research of Non- Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH), and other diseases involving fibrosis, steatosis, or inflammation of the liver .

HY-D1196

Direct Blue 71	Fluorescent Dye
Direct Blue 71 is a good dyeing agent for cotton fabrics and can be adsorbed by palm ash and removed from the aqueous solution.

HY-W166297

Esculin sesquihydrate	p38 MAPK	Cancer
Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .

HY-141429

AS-99 free base	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-141429C

AS-99	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-141429A

AS-99 TFA	Histone Methyltransferase Apoptosis	Cancer
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-N0188

Esculin 4 Publications Verification	p38 MAPK	Inflammation/Immunology Cancer
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-121471R

Chrysoeriol (Standard)	Endogenous Metabolite	Metabolic Disease
Chrysoeriol (Standard) is the analytical standard of Chrysoeriol. This product is intended for research and analytical applications. Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-N0188R

Esculin (Standard)	p38 MAPK	Inflammation/Immunology Cancer
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

Cat. No.	Product Name	Type

HY-D1196

Direct Blue 71	Dyes
Direct Blue 71 is a good dyeing agent for cotton fabrics and can be adsorbed by palm ash and removed from the aqueous solution.

Cat. No.	Product Name	Type

HY-W111589F

*Kieselguhr, soda ash* flux-calcined**	Biochemical Assay Reagents
Kieselguhr, soda ash flux-calcined is a filter aid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6990

Anhydrosecoisolariciresinol	other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-121471

Chrysoeriol 1 Publications Verification	Structural Classification Classification of Application Fields Flavones Metabolic Disease Plants Phyllanthus Flavonoids Phenols Polyphenols Euphorbiaceae Brassicaceae Disease Research Fields Coronopus didymus	Endogenous Metabolite
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-N0188

Esculin 4 Publications Verification	Structural Classification Monophenols other families Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer	p38 MAPK
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-121471R

Chrysoeriol (Standard)	Structural Classification Flavonoids Flavones Phenols Polyphenols Euphorbiaceae Plants Brassicaceae Phyllanthus Coronopus didymus	Endogenous Metabolite
Chrysoeriol (Standard) is the analytical standard of Chrysoeriol. This product is intended for research and analytical applications. Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-N0188R

Esculin (Standard)	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants	p38 MAPK
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70396

	Grb2 Protein, Human (His) rHuGrowth factor receptor-bound protein 2/GRB2, His; Growth Factor Receptor-Bound Protein 2; Adapter Protein GRB2; Protein ASH; SH2/SH3 Adapter GRB2; GRB2; ASH	Human	E. coli
	Grb2, an adapter protein, crucially connects cell surface growth factor receptors to the Ras signaling pathway. Despite no direct binding to phosphorylated EGFR, Grb2 inhibits EGF-induced transactivation of a RAS-responsive element. It acts as a dominant negative relative to GRB2, suppressing proliferative signals and potentially initiating programmed cell death. Grb2 Protein, Human (His) is the recombinant human-derived Grb2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702887

	*MLL3-WDR5-Ash2L-RbBP5-DPY30 Protein, Human (His)* HALR; KIAA1506; MLL3; WDR5; ASH2L; RbBP5; DPY30	Human	E. coli

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80695

	GRB2 Antibody (YA748) GRB2; ASH; Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein ASH; SH2/SH3 adapter GRB2	WB	Human, Mouse, Rat
	GRB2 Antibody (YA748) is a non-conjugated and Mouse origined monoclonal antibody about 25 kDa, targeting to GRB2 (5G3). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81978

	ASH2L Antibody (YA1723) ASH2; Bre2; ASH2L1; ASH2L2	WB, ICC/IF, IP	Human, Rat
	ASH2L Antibody (YA1723) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1723), targeting ASH2L, with a predicted molecular weight of 69 kDa (observed band size: 80 kDa). ASH2L Antibody (YA1723) can be used for WB, ICC/IF, IP experiment in human, rat background.

HY-P81381

	MASH1/Achaete-scute homolog 1 Antibody (YA1126) ASCL1; ASH1, BHLHA46; HASH1; Achaete-scute homolog 1; ASH-1; hASH1 ; Class A basic helix-loop-helix protein 46	IHC-P	Human
	MASH1/Achaete-scute homolog 1 Antibody (YA1126) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1126), targeting MASH1/Achaete-scute homolog 1. MASH1/Achaete-scute homolog 1 Antibody (YA1126) can be used for IHC-P experiment in human background.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS01087

ASH1L Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ASH1L Human Pre-designed siRNA Set A contains three designed siRNAs for ASH1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01088

ASH2L Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ASH2L Human Pre-designed siRNA Set A contains three designed siRNAs for ASH2L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

ASH

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products