ATF1

By Targets:	5-HT Receptor (1) Akt (1) Epigenetic Reader Domain (1) FOXO (1) Mitochondrial Metabolism (1) Phosphodiesterase (PDE) (1) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Endocrinology (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108618

BC11-38 1 Publications Verification	Phosphodiesterase (PDE)	Endocrinology
BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC₅₀s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells ^[1].

HY-103100

SB-699551 1 Publications Verification	5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO	Neurological Disease Cancer
SB-699551 is a potent and selective 5-HT5A antagonist with a K_i value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and *ATF1, and decreases the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP*. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer.

HY-RS01127

ATF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATF1 Human Pre-designed siRNA Set A ATF1 Human Pre-designed siRNA Set A

HY-RS24816

Atf1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atf1 Rat Pre-designed siRNA Set A Atf1 Rat Pre-designed siRNA Set A

HY-RS18337

Atf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atf1 Mouse Pre-designed siRNA Set A Atf1 Mouse Pre-designed siRNA Set A

HY-N12887

Mycothiazole	Mitochondrial Metabolism	Others Cancer
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12887

Mycothiazole	Structural Classification Natural Products Marine natural products Source classification Sponge	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans ^[1].

Species:	Human (3) Rat (1) Canine (1)
Tag:	His (2) Tag Free (2) Fc (1)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7615

	ATF1 Protein, Human (His) rHuATF1, His; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1	Human	E. coli
	ATF1 Protein, Human (His) expressed in E. coli with a His tag. ATF1 is a member of the ATF/CREB family of transcription factors (TFs), specifically interacting with the consensus ATF/CRE site ‘TGACGTCA’.

HY-P7182

	GDNF Protein, Human 1 Publications Verification rHuGDNF; ATF	Human	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human is produced in E.coil, and consists of 134 amino acids (S78-I211).

HY-P75169

	GDNF Protein, Canine (HEK293, Fc) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Canine	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Canine (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 103 amino acids (R109-I211).

HY-P73074

	GDNF Protein, Human (HEK293) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Human	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human (HEK293) is produced in HEK293 cells, and consists of 103 amino acids (R83-I185).

HY-P73075

	GDNF Protein, Rat (sf9, His) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Rat	Sf9 insect cells
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Rat (sf9, His) is produced in Sf9 insect cells with a N-Terminal His-tag. It consists of 134 amino acids (S78-I211).

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83391

	ATF1 Antibody (YA3136) Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1 Protein TREB36; ATF1	WB, ICC/IF, IP	Human
	ATF1 Antibody (YA3136) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3136), targeting ATF1, with a predicted molecular weight of 29 kDa (observed band size: 36 kDa). ATF1 Antibody (YA3136) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82746

	GDNF Antibody (YA2491) ATF1; ATF2; gdnf; HFB1 GDNF; hGDNF; HSCR3	WB, FC	Human, Mouse, Rat
	GDNF Antibody (YA2491) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2491), targeting GDNF, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). GDNF Antibody (YA2491) can be used for WB, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS01127

ATF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24816

Atf1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Atf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18337

Atf1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Atf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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