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Results for "

Anti-virulence

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-146327
    PqsR/LasR-IN-1

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA .
    PqsR/LasR-IN-1
  • HY-130613
    MAC-545496

    		Bacterial Infection
    MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) .
    MAC-545496
  • HY-146328
    PqsR/LasR-IN-2

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM .
    PqsR/LasR-IN-2
  • HY-124469
    UM-C162

    		Bacterial Infection
    UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of i>S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control i>S. aureus infections .
    UM-C162
  • HY-163542
    Pneumolysin-IN-1

    		Bacterial Inflammation/Immunology
    Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae .
    Pneumolysin-IN-1
  • HY-157322
    SAV13

    		Fluorescent Dye Infection
    SAV13 is an inhibitor of SaeR. SAV13 is an analogue of HR3744. SAV13 inhibits SaeR-DNA probe binding and has antivirulence properties .
    SAV13
  • HY-P10200
    CP7-FP13-2

    		Bacterial Infection
    CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
    CP7-FP13-2
  • HY-162496
    L-NBDNJ

    		Bacterial Infection Inflammation/Immunology
    L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has anti-inflammatory and anti-infective effects in models of cystic fibrosis (CF) lung disease infection .
    L-NBDNJ
  • HY-161124
    Antibacterial agent 175

    		Bacterial Infection
    Antibacterial agent 175 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. Antibacterial agent 175 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. Antibacterial agent 175 is an antivirulence agent against S. aureus infections .
    Antibacterial agent 175
  • HY-168061
    HldA/E-IN-1

    		Bacterial Infection
    HldA/E-IN-1 (compound 8) is a dual inhibitor of HldA/E, with IC50 values ​​of 17.2 μM and 67.8 μM for HldA/E, respectively. HldA/E-IN-1 can be used in the study of anti-bacterial infection .
    HldA/E-IN-1
  • HY-146329
    PqsR/LasR-IN-3

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 µM .
    PqsR/LasR-IN-3
  • HY-151160
    LasR-IN-1

    		Bacterial Infection
    LasR-IN-1 (compound 9g) is a potent LasR inhibitor. LasR-IN-1 has good efficacy toward E. coli. LasR-IN-1 shows anti-bacterial activity, with a MIC of 28.13 μM against P. aeruginosa .
    LasR-IN-1

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