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AurkA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Aurora Kinase (16) Bacterial (1) Bcr-Abl (1) c-Myc (2) FLT3 (1) Histone Methyltransferase (1) Mps1 (2) PROTACs (5) Small Interfering RNA (siRNA) (3) VEGFR (1)
By Research Areas:	Cancer (18) Infection (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137344A

dAURK-4 hydrochloride	PROTACs Aurora Kinase	Cancer
dAURK-4 hydrochloride, an Alisertib (HY-10971) derivative, is a potent and selective *PROTAC AURKA* (Aurora A)** degrader. dAURK-4 hydrochloride has anticancer effects. (Pink: Ligand for target protein (HY-10971); Black: Linker (HY-W004640); Blue: Ligand for E3 ligase Thalidomide-O-COOH (HY-103597)) .

HY-112273

CD532	Aurora Kinase	Cancer
CD532 is a potent Aurora A kinase inhibitor with an IC₅₀ of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer .

HY-161407

AURKA-IN-1	Aurora Kinase	Cancer
AURKA-IN-1 (compound 9) is an cell-active covalent *AURKA* inhibitor. AURKA-IN-1 is a lysine-reactive activity probe .

HY-158038

AurkA allosteric-IN-1	Aurora Kinase	Cancer
AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC₅₀: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .

HY-162837

AURKA against 1	Aurora Kinase	Cancer
AURKA against 1 is an inhibitor of *AURKA* (IC₅₀ less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3 .

HY-RS01266

AURKA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AURKA Human Pre-designed siRNA Set A contains three designed siRNAs for AURKA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AURKA Human Pre-designed siRNA Set A AURKA Human Pre-designed siRNA Set A

HY-RS01267

Aurka Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aurka Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurka gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurka Mouse Pre-designed siRNA Set A Aurka Mouse Pre-designed siRNA Set A

HY-RS01268

Aurka Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aurka Rat Pre-designed siRNA Set A contains three designed siRNAs for Aurka gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurka Rat Pre-designed siRNA Set A Aurka Rat Pre-designed siRNA Set A

HY-155464

*VEGFR-2/AURKA-IN-1*	VEGFR Aurora Kinase	Cancer
VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC₅₀: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential .

HY-137344

dAURK-4	PROTACs Aurora Kinase	Cancer
dAURK-4, an Alisertib (HY-10971) derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects .

HY-112273A

CD532 hydrochloride	Aurora Kinase	Cancer
CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC₅₀ of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer .

HY-168543

PROTAC MPS1 degrader 2	PROTACs Aurora Kinase Mps1	Cancer
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), *AURKA* and AURKB, with DC₅₀s of 42.0, 2.1 and 154.0 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984) .

HY-168540

PROTAC MPS1 degrader 1	PROTACs Mps1 Aurora Kinase	Cancer
PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), *AURKA* and AURKB, with DC₅₀s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984) .

HY-100865

BPR1K871 DBPR114	FLT3	Cancer
BPR1K871 is a potent and selective dual *FLT3/AURKA* inhibitor with IC₅₀s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-157396

JAB-2485	Aurora Kinase Apoptosis	Cancer
JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC₅₀ of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer .

HY-162469

6K465	Aurora Kinase c-Myc	Cancer
6K465 is a pyrimidine-based Aurora A (AURKA) inhibitor. 6K465 can reduce the levels of c-MYC and N-MYC oncoproteins, demonstrating anticancer activity .

HY-125956

Aurkin A	Aurora Kinase	Cancer
Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also *Aurka) and TPX2, through targeting the TPX2 binding sites with K_d* of 3.77 μM .

HY-147703

Aurora kinase inhibitor-9	Aurora Kinase	Cancer
Aurora kinase inhibitor-9 (compound 9d) is a potent *AURKA/B* dual aurora kinase inhibitor with IC₅₀s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity .

HY-103645

GW779439X	Bacterial Aurora Kinase Apoptosis	Infection Cancer
GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an *AURKA* inhibitor and induces apoptosis by the caspases 3/7 pathway . MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus

HY-125090

PHA-680626	Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis	Cancer
PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells .

Species:	Human (3)
Tag:	Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702672

	AURKA Protein, Human (sf9, GST) AurkA; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47	Human	Sf9 insect cells
	AURA is a mitotic serine/threonine kinase that complexly controls cell cycle progression and various mitotic events. AURA associates with centrosomes and spindle microtubules during mitosis and plays a critical role in spindle establishment, centrosome duplication, chromosome alignment, spindle assembly checkpoint activation, and cytokinesis. AURKA Protein, Human (sf9, GST) is the recombinant human-derived AURKA, expressed by Sf9 insect cells , with GST labeled tag. The total length of AURKA Protein, Human (sf9, GST) is 402 a.a.,

HY-P702867

	AURKA-INCENP Heterodimer Protein, Human (sf9, GST, His, Strep) AurkA; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47	Human	Sf9 insect cells

HY-P701706

	AURA Protein, Human (Sf9) AurkA; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A	Human	Sf9 insect cells
	AURA is a mitotic serine/threonine kinase that complexly controls cell cycle progression and various mitotic events. AURA associates with centrosomes and spindle microtubules during mitosis and plays a critical role in spindle establishment, centrosome duplication, chromosome alignment, spindle assembly checkpoint activation, and cytokinesis. AURA Protein, Human (Sf9) is the recombinant human-derived AURA protein, expressed by Sf9 insect cells , with tag free. The total length of AURA Protein, Human (Sf9) is 402 a.a., .

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Cat. No.	Product Name		Classification

HY-161407

AURKA-IN-1		Alkynes
AURKA-IN-1 (compound 9) is an cell-active covalent *AURKA* inhibitor. AURKA-IN-1 is a lysine-reactive activity probe .

AURKA Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AURKA Human Pre-designed siRNA Set A contains three designed siRNAs for AURKA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurka Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Aurka Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurka gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurka Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Aurka Rat Pre-designed siRNA Set A contains three designed siRNAs for Aurka gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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