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Results for "

Azadirachta indica

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

11

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123026
    Salannin

    		Bacterial Infection
    Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .
    Salannin
  • HY-133108
    Azadirachtin B

    		EBV Parasite Phosphatase Influenza Virus Infection Metabolic Disease Inflammation/Immunology Cancer
    Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .
    Azadirachtin B
  • HY-116035
    Nimbolide
    1 Publications Verification

    		 NF-κB CDK Apoptosis Cancer
    Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways .
    Nimbolide
  • HY-N1710
    28-Deoxonimbolide

    		Apoptosis Caspase Cancer
    28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .
    28-Deoxonimbolide
  • HY-121731
    Nimbocinone

    		Others Metabolic Disease
    Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity .
    Nimbocinone
  • HY-N3695
    6-Deacetylnimbinene

    		Others Others
    6-Deacetylnimbinene is a triterpenoid product that can be isolated from Azadirachta indica A. Juss .
    6-Deacetylnimbinene
  • HY-N9615
    Azadiradione

    		HSP Infection Neurological Disease Inflammation/Immunology
    Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .
    Azadiradione
  • HY-163450
    Nimbiol

    		Bacterial Infection
    Nimbiol exhibits binding energy for FtsZ and shows potential anti-FtsZ effect .
    Nimbiol
  • HY-N3694
    Deacetylnimbin

    Desacetyl nimbin

    		 Others Others
    Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .
    Deacetylnimbin
  • HY-N1654
    2',3'-Dehydrosalannol

    		Bacterial Infection
    2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .
    2',3'-Dehydrosalannol
  • HY-N10096
    Epoxyazadiradione

    		Parasite Infection
    Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .
    Epoxyazadiradione
  • HY-N10091
    2,3-Dihydro-3α-methoxynimbolide

    		Apoptosis Others
    2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .
    2,3-Dihydro-3α-methoxynimbolide

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