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Results for "

BRD7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Epigenetic Reader Domain (15) PROTACs (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (11) Inflammation/Immunology (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149420

BRD7-IN-2	Epigenetic Reader Domain	Others
BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.

HY-111905

BRD7-IN-1	Epigenetic Reader Domain	Cancer
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC₅₀s of 4.5 and 1.8 nM, respectively) .

HY-100517

TP-472	Epigenetic Reader Domain Apoptosis	Cancer
TP-472 is a selective *BRD9/7* inhibitor, with K_ds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7 . TP-472 induces apoptosis of melanoma cells .

HY-19553

LP99	Epigenetic Reader Domain	Inflammation/Immunology
LP99, an epigenetic probe, is a potent and selective inhibitor of the *BRD7* and *BRD9* bromodomains with a K_d of 99 nM against BRD9. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells .

HY-RS01606

BRD7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BRD7 Human Pre-designed siRNA Set A contains three designed siRNAs for BRD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BRD7 Human Pre-designed siRNA Set A BRD7 Human Pre-designed siRNA Set A

HY-RS01607

Brd7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brd7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brd7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brd7 Mouse Pre-designed siRNA Set A Brd7 Mouse Pre-designed siRNA Set A

HY-RS01608

Brd7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brd7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brd7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brd7 Rat Pre-designed siRNA Set A Brd7 Rat Pre-designed siRNA Set A

HY-149421

BRD7-IN-3	Epigenetic Reader Domain	Cancer
BRD7-IN-3 (compound 1-78) is a dual inhibitor of bromodomain-containing proteins BRD7/BRD9 with IC₅₀s of 1.6 μM and 2.7 μM respectively .

HY-111905A

BRD7-IN-1 free base	Epigenetic Reader Domain	Cancer
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC₅₀s of 4.5 and 1.8 nM, respectively) .

HY-116227

(2S,3R)-LP99	Epigenetic Reader Domain	Inflammation/Immunology
(2S,3R)-LP99 is a potent and selective *BRD7* and *BRD9* inhibitor with an K_D of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion .

HY-114322A

cis-VZ185	PROTACs Epigenetic Reader Domain	Others
cis-VZ185 is a VHL-based PROTACs degrader with the activity of degrading BRD9 and BRD7. cis-VZ185 can be optimized from suboptimal compounds by optimizing the connection mode and linker, and has efficient, rapid and selective degradation of BRD9 and its homologous protein BRD7.

HY-136192

TP-472N	Epigenetic Reader Domain	Cancer
TP-472N is a negative control probe for TP-472. TP-472 is a potent and selective BRD7/9 probe .

HY-100351

BI-7273	Epigenetic Reader Domain	Cancer
BI-7273 is a selective, and cell-permeable *BRD9* inhibitor, with an IC₅₀ and a K_d of 19 and 0.75 nM; also shows high effect on BRD7, with an IC₅₀ and a K_d of 117 nM and 0.3 nM.

HY-100352

BI-9564 1 Publications Verification	Epigenetic Reader Domain	Cancer
BI-9564 is a potent, selective and cell-permeable BRD9/BRD7 bromodomains inhibitor, with IC₅₀s of 75 nM and 3.4 μM and K_ds of 14 nM and 239 nM, respectively. BI-9564 has an IC₅₀ of > 100 μM for BET family .

HY-156744

DBr-1	PROTACs Epigenetic Reader Domain	Cancer
DBr-1 is a potent *BRD9* PROTAC degrader (K_D: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352) .

HY-149806

Bromodomain IN-2	Epigenetic Reader Domain	Cancer
BD-IN-1 is a pan bromodomain (BD) inhibitor with K_D values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity .

HY-114322

VZ185 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of *BRD9* and *BRD7* with DC₅₀s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC₅₀s of 3 nM and 40 nM, respectively .

HY-18975

*I-BRD9* 5 Publications Verification	Epigenetic Reader Domain	Inflammation/Immunology Cancer
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC₅₀ value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways .

BRD7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BRD7 Human Pre-designed siRNA Set A contains three designed siRNAs for BRD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brd7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Brd7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brd7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brd7 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Brd7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brd7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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