Bromodomain IN-2

Cat. No.: HY-149806: FAQs
Data Sheet Handling Instructions

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BD-IN-1 is a pan bromodomain (BD) inhibitor with K_D values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity.

For research use only. We do not sell to patients.

Bromodomain IN-2 Chemical Structure

CAS No. : 2445335-77-1

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Description

IC₅₀ & Target^[1]

BRD4(1)

250 nM (Kd)

BRPF1b

130 nM (Kd)

BRD7

430 nM (Kd)

BRD9

67 nM (Kd)

BRDT (1)

240 nM (Kd)

CBP

420 nM (Kd)

CECR2

970 nM (Kd)

In Vitro

BD-IN-1 (compound 3; 0-100 µM) shows antiproliferative activity with GI₅₀s of 182, 479, 708 nM for SNB-75, UO-31, CAKI-1 cells, and 13.2, 12.0, 10.2 µM for DU-145, SW-620, NCI-H460 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.77

Formula

C₁₆H₁₇ClN₂O

CAS No.

2445335-77-1

SMILES

O=C1C2=C(C)NC(C3=C(Cl)C=CC(N)=C3)=C2CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Warstat R, et al. A novel pan-selective bromodomain inhibitor for epigenetic drug design. Eur J Med Chem. 2023 Mar 5;249:115139. [Content Brief]

Bromodomain IN-2 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromodomain IN-22445335-77-1Bromodomain IN2Bromodomain IN 2Epigenetic Reader Domainantiproliferativepan-inhibitorInhibitorinhibitorinhibit

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