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CAV-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (1) Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (1) Calcium Channel (13) Endogenous Metabolite (2) Fungal (4) Integrin (1) Isotope-Labeled Compounds (4) Oxidative Phosphorylation (1) P2Y Receptor (1) Potassium Channel (1) Reactive Oxygen Species (5) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (12) Infection (4) Neurological Disease (4)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134542

CaV1.3 antagonist-1	Calcium Channel	Neurological Disease
CaV1.3 antagonist-1 is a potent and highly selective Ca_V1.3 L-type calcium channel (LTCC) antagonist with an IC₅₀ of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca_V1.3 LTCC >600-fold more potently than Ca_V1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research ^[1].

HY-106454

N-Desalkylflurazepam Norfludiazepam	Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for *Ca_v1.2* and *Ca_v1.3*, respectively ^[1] .

HY-RS01986

CAV1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAV1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAV1 Human Pre-designed siRNA Set A CAV1 Human Pre-designed siRNA Set A

HY-106454R

N-Desalkylflurazepam (Standard)	Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively ^[1] .

HY-N6687R

Calcimycin (Standard)	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively ^[1] .

HY-17402S

Nisoldipine-d6 BAY-k 5552-d₆	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-17402R

Nisoldipine (Standard)	Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-17402S3

Nisoldipine-d3 BAY-k 5552-d₃	Calcium Channel Reactive Oxygen Species Isotope-Labeled Compounds	Cardiovascular Disease
Nisoldipine-d₃ is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-122552

Chrysotobibenzyl	Integrin	Cancer
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) ^[1].

HY-17402S1

Nisoldipine-d4	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine-d₄ (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-17402S2

Nisoldipine-d7	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine-d₇ (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-118202A

(-)-Gallopamil hydrochloride (-)-Methoxyverapamil hydrochloride	Calcium Channel	Cardiovascular Disease
(-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently *Cav1.2* constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics ^[1] .

HY-118202

(-)-Gallopamil (-)-Methoxyverapamil	Calcium Channel	Cardiovascular Disease
(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently *Cav1.2* constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil is promising for research of antiarrhythmics ^[1] .

HY-159090

AT1R antagonist 3	Calcium Channel Angiotensin Receptor	Cardiovascular Disease
AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV_1.2 (IC₅₀=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models ^[1].

HY-146173

KCa1.1 channel activator-1	Potassium Channel Calcium Channel	Cardiovascular Disease
KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular K_Ca1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays Ca_V1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity ^[1].

HY-B1858

Isoprothiolane	Fungal	Infection
Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav .

HY-N12859

Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside	Others	Others
Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside is a flavonoid glycoside that can be isolated from Malope trifida Cav .

HY-B1858S

Isoprothiolane-d4	Fungal	Infection
Isoprothiolane-d₄ is the deuterium labeled Isoprothiolane. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1][2].

HY-B1858R

Isoprothiolane (Standard)	Fungal	Infection
Isoprothiolane (Standard) is the analytical standard of Isoprothiolane. This product is intended for research and analytical applications. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty?Pyvioutavia oryzae?Cav .

HY-156889

Cav 3.1 blocker 1	Calcium Channel	Neurological Disease
Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC₅₀value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC₅₀ of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC₅₀ of >10000 nM) ^[1].

HY-116307

2-Thio-UTP	P2Y Receptor	Cardiovascular Disease
2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

HY-112499

Menaquinone-7 1 Publications Verification Vitamin K2-7; Vitamin K2(35); Vitamin MK-7	Endogenous Metabolite	Cardiovascular Disease
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-112499R

Menaquinone-7 (Standard) Vitamin K2-7(Standard); Vitamin K2(35)(Standard); Vitamin MK-7 (Standard)	Endogenous Metabolite	Cardiovascular Disease
Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

Cat. No.	Product Name	Target	Research Area

HY-P2288A

WL47 TFA 2 Publications Verification	Peptides	Cancer
WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function ^[1].

HY-P10332

WL 47 dimer	Peptides	Others
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of *CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1* function ^[1].

HY-P2288

WL47	Peptides	Cancer
WL47, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of *CAV1* oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6687R

Calcimycin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively ^[1] .

HY-122552

Chrysotobibenzyl	Structural Classification Natural Products Orchidaceae Source classification Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Integrin
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) ^[1].

HY-N12859

Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside	Malvaceae Structural Classification Flavonoids Flavones Malva sinensis Cav. Source classification Plants	Others
Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside is a flavonoid glycoside that can be isolated from Malope trifida Cav .

Cat. No.	Product Name	Chemical Structure

HY-17402S

Nisoldipine-d6
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-17402S3

Nisoldipine-d3
Nisoldipine-d₃ is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-17402S1

Nisoldipine-d4
Nisoldipine-d₄ (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-17402S2

Nisoldipine-d7
Nisoldipine-d₇ (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-B1858S

Isoprothiolane-d4
Isoprothiolane-d₄ is the deuterium labeled Isoprothiolane. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82037

	Caveolin 1 Antibody (YA1782) CAV1; CAV; CAVeolin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Caveolin 1 Antibody (YA1782) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1782), targeting Caveolin 1, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). Caveolin 1 Antibody (YA1782) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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CAV1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CAV1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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CAV-1

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products