CBS

By Targets:	Apoptosis (1) Autophagy (1) Bacterial (1) CRM1 (1) Drug Derivative (1) Endogenous Metabolite (2) ERK (1) Herbicide (1) Influenza Virus (1) Insulin Receptor (1) Lipoxygenase (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (1) p38 MAPK (2) Phosphodiesterase (PDE) (1) Small Interfering RNA (siRNA) (3) TRP Channel (1)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131059

CBS1117	Influenza Virus	Infection
CBS1117 is a virus entry inhibitor with an IC₅₀ of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1). CBS1117 interferes with the hemagglutinin (HA)-mediated fusion process .

HY-15300

Skepinone-L 1 Publications Verification CBS3830	p38 MAPK Autophagy	Inflammation/Immunology
Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.

HY-108716

Felezonexor CBS9106; SL-801	CRM1 Apoptosis	Cancer
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells .

HY-105983A

CBS-1114 hydrochloride	Lipoxygenase	Inflammation/Immunology
CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor. CBS-1114 hydrochloride has the potential for inflammation and inflammation-related disorders research .

HY-111164

CBS-3595	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases .

HY-101556

Namirotene CBS-211A	Drug Derivative	Cancer
Namirotene (CBS-211A) is a retinoic acid analog, which is utilized in topical eye administration. Namirotene enhances 1α,25-dihydroxyvitamin D3-induced cytotoxicity in cell U937 and induces the differentation in U937 .

HY-RS02007

CBS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBS Human Pre-designed siRNA Set A contains three designed siRNAs for CBS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBS Human Pre-designed siRNA Set A CBS Human Pre-designed siRNA Set A

HY-RS17100

Cbs Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cbs Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbs gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cbs Mouse Pre-designed siRNA Set A Cbs Mouse Pre-designed siRNA Set A

HY-RS23544

Cbs Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cbs Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbs gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cbs Rat Pre-designed siRNA Set A Cbs Rat Pre-designed siRNA Set A

HY-P5343

p53 CBS p53 Consensus binding sequence	MDM-2/p53	Others
p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

HY-12852

Diclosulam XDE 564	Herbicide Bacterial	Infection
Diclosulam (XDE 564) is a herbicide with a K_i value of ＜32 nM and MIC and MIC₅₀ values of 6.25, 1.40, 12.5 and 3.01 μM against CBS10913 and CBS12373 strains, respectively .

HY-163523

PYRIB-SO 2	Microtubule/Tubulin	Cancer
PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin .

HY-121841

Cannabidiorcol O-1821; CBD-C1	TRP Channel	Inflammation/Immunology Cancer
Cannabidiorcol (CBDO, CBD-C1, O-1821) is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors (CBs) and is an agonist of the transient receptor potential channel (TRP channel), through which it produces antiinflammatory effects, but can also promote tumorigenesis at high concentrations .

HY-Y0337

L-Cysteine Maximum Cited Publications 8 Publications Verification Cysteine	Endogenous Metabolite ERK	Neurological Disease Metabolic Disease Cancer
L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent .

HY-W016715

L-Cysteine hydrochloride hydrate Maximum Cited Publications 8 Publications Verification	Endogenous Metabolite NF-κB Insulin Receptor	Neurological Disease Metabolic Disease
L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates *CBS/H2S* pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P5343

p53 CBS p53 Consensus binding sequence	MDM-2/p53	Others
p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0337

L-Cysteine 5+ Cited Publications Cysteine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite ERK
L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent .

HY-W016715

L-Cysteine hydrochloride hydrate 5+ Cited Publications	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite NF-κB Insulin Receptor
L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates *CBS/H2S* pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .

Cat. No.	Compare	Product Name	Species	Source

HY-P72118

	CBS Protein, Human (His) AI047524; AI303044; Beta thionase; Beta-thionase; CBS; CBS cystathionine beta-synthase; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase	Human	E. coli
	CBS, a hydro-lyase, initiates the transsulfuration pathway by catalyzing the beta-replacement reaction, converting L-serine to L-cystathionine using L-homocysteine. This process eliminates L-methionine and the potentially harmful metabolite L-homocysteine. CBS, beyond its catabolic role, contributes to hydrogen sulfide production, serving as a gasotransmitter with signaling and cytoprotective effects, particularly on neurons. CBS Protein, Human (His) is the recombinant human-derived CBS protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82403

	CBS Antibody (YA2148) HIP4; CBS	WB, IHC-P, ICC/IF	Human
	CBS Antibody (YA2148) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2148), targeting CBS, with a predicted molecular weight of 61 kDa (observed band size: 61 kDa). CBS Antibody (YA2148) can be used for WB, IHC-P, ICC/IF experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS02007

CBS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CBS Human Pre-designed siRNA Set A contains three designed siRNAs for CBS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17100

Cbs Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cbs Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbs gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23544

Cbs Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cbs Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbs gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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