2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Cysteine

L-Cysteine  (Synonyms: Cysteine)

Cat. No.: HY-Y0337 Purity: ≥97.0%
SDS COA Handling Instructions

Molarity Calculator

L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.

For research use only. We do not sell to patients.

L-Cysteine Chemical Structure

L-Cysteine Chemical Structure

CAS No. : 52-90-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
500 mg USD 50 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of L-Cysteine:

L-Cysteine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
161 μM
Compound: 5862
Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells
Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells
10.5281/zenodo.7361326
HEK293 EC50
376 μM
Compound: 5862
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells
10.5281/zenodo.6782621
SNB-19 IC50
116 μM
Compound: L-cystine
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting
[PMID: 19932968]
Clinical Trial
Molecular Weight

121.16

Formula

C3H7NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (275.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.2535 mL 41.2674 mL 82.5348 mL
5 mM 1.6507 mL 8.2535 mL 16.5070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (825.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (245 KB) HNMR (211 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.2535 mL 41.2674 mL 82.5348 mL 206.3370 mL
5 mM 1.6507 mL 8.2535 mL 16.5070 mL 41.2674 mL
10 mM 0.8253 mL 4.1267 mL 8.2535 mL 20.6337 mL
15 mM 0.5502 mL 2.7512 mL 5.5023 mL 13.7558 mL
20 mM 0.4127 mL 2.0634 mL 4.1267 mL 10.3169 mL
25 mM 0.3301 mL 1.6507 mL 3.3014 mL 8.2535 mL
30 mM 0.2751 mL 1.3756 mL 2.7512 mL 6.8779 mL
40 mM 0.2063 mL 1.0317 mL 2.0634 mL 5.1584 mL
50 mM 0.1651 mL 0.8253 mL 1.6507 mL 4.1267 mL
60 mM 0.1376 mL 0.6878 mL 1.3756 mL 3.4390 mL
80 mM 0.1032 mL 0.5158 mL 1.0317 mL 2.5792 mL
100 mM 0.0825 mL 0.4127 mL 0.8253 mL 2.0634 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Cysteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cysteine52-90-4CysteineEndogenous MetaboliteconditionallyhydrogensulphideH2SglutathionetaurineghrelinappetiteInhibitorinhibitorinhibit

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