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Isoforms Recommended:	CCR3

Results for "

CCR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CCR (13) HIV (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Endocrinology (4) Infection (1) Inflammation/Immunology (12) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00331

CCR3 antagonist 1 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
CCR3 antagonist 1 is a potent antagonist of *CCR3*, used for the research of immunologic and inflammatory diseases.

HY-103360

J-113863 3 Publications Verification	CCR	Inflammation/Immunology
J-113863 is a potent and selective *CCR1* antagonist with IC₅₀ values of 0.9 nM and 5.8 nM for human and mouse *CCR1* receptors, respectively. J-113863 is also a potent antagonist of the human *CCR3* (IC₅₀ of 0.58 nM) , but a weak antagonist of the mouse *CCR3* (IC₅₀ of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect ^[3].

HY-136788

ALK4290 AKST4290	CCR	Neurological Disease Inflammation/Immunology
ALK4290 (AKST4290) is a potent and orally active *CCR3* inhibitor extracted from patent US20130261153A1, compound Example 2, with a K_i of 3.2 nM for hCCR3 . ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism ^[3].

HY-103363

SB-328437 1 Publications Verification	CCR	Inflammation/Immunology
SB-328437 is a potent, selective non-peptide *CCR3* antagonist with an IC₅₀ of 4.5 nM .

HY-103361

SB297006 1 Publications Verification	CCR	Neurological Disease Endocrinology
SB297006 is a *CCR3* antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

HY-RS02154

CCR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCR3 Human Pre-designed siRNA Set A CCR3 Human Pre-designed siRNA Set A

HY-RS02155

Ccr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr3 Mouse Pre-designed siRNA Set A Ccr3 Mouse Pre-designed siRNA Set A

HY-RS02156

Ccr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr3 Rat Pre-designed siRNA Set A Ccr3 Rat Pre-designed siRNA Set A

HY-N10397

Maceneolignan H	CCR	Inflammation/Immunology
Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC₅₀ = 1.4 μM). Maceneolignan H has the potential for the research of allergic diseases .

HY-103360B

trans-J-113863	CCR	Inflammation/Immunology
trans-J-113863 is a potent chemokine *CCR1* and *CCR3* receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC₅₀ of 9.57 and 93.8 nM,respectively .

HY-111198

YM-355179 fumarate	Others	Inflammation/Immunology
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC₅₀ values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC₅₀ The values are 8.0 nM, 24 nM and 29 nM respectively .

HY-160998

YM-344031	CCR	Inflammation/Immunology
YM-344031 is an orally active antagonist for *CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC₅₀* of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca ^[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model .

HY-107051

GW 766994 2 Publications Verification GW 994	CCR	Inflammation/Immunology Endocrinology
GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research .

HY-136788A

ALK4290 dihydrochloride AKST4290 dihydrochloride	CCR	Inflammation/Immunology
ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active *CCR3* inhibitor extracted from patent US20130261153A1, compound Example 2, with a K_i of 3.2 nM for hCCR3 . ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism ^[3].

HY-P3982

CKLF1-C19	CCR	Inflammation/Immunology
CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with *CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3* and CCR4 .

HY-19974

TAK-220 2 Publications Verification	CCR HIV	Infection Endocrinology
TAK-220 is a selective and orally bioavailable *CCR5* antagonist, with IC₅₀s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC₅₀s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC₉₀s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.

HY-120629

BMS-639623	CCR	Inflammation/Immunology
BMS-639623 is a potent and orally activeCCR3 antagonist with an IC₅₀ of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC₅₀=38 pM). BMS-639623 can be used for the research of asthma .

Cat. No.	Product Name	Target	Research Area

HY-P3982

CKLF1-C19	CCR	Inflammation/Immunology
CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with *CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3* and CCR4 .

*Anti-Mouse CCR3/CD193) Antibody (6S2-19-4)*	Inhibitory Antibodies	Others
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) is a rat-derived IgG2b, λ type antibody inhibitor, targeting to mouse CCR3/CD193).

Maceneolignan H	Structural Classification Natural Products Classification of Application Fields Source classification Myristicaceae Plants Myristica fragrans Houtt. Inflammation/Immunology Disease Research Fields	CCR
Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC₅₀ = 1.4 μM). Maceneolignan H has the potential for the research of allergic diseases .

CCR3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr3 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ccr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr3 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ccr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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