CD31

By Targets:	Antibiotic (2) Apoptosis (1) Bacterial (4) Calcium Channel (1) DNA/RNA Synthesis (1) Isotope-Labeled Compounds (3) Ser/Thr Protease (1) SHP2 (2) Transmembrane Glycoprotein (1) VEGFR (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3444

*CD31* PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P3325

P8RI D-P8RI	VEGFR	Inflammation/Immunology
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a *CD31* agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway .

HY-W654064

Azithromycin-13C,d3-1	Isotope-Labeled Compounds	Others
Azithromycin-13C,d3-1 is a deuterated labeled Azithromycin-13C,d3-1 .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P990277

*Anti-Mouse CD31/PECAM-1 Antibody (390)*	Transmembrane Glycoprotein	Others
Anti-Mouse CD31/PECAM-1 Antibody (390) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD31/PECAM-1.

HY-E70527

Proteinase 3 (PR3), Human Neutrophil	Ser/Thr Protease	Inflammation/Immunology
Proteinase 3 (PR3), Human Neutrophil is a neutrophils secreted serine protease. Proteinase 3 (PR3), Human Neutrophil binds to phosphatidylserine, affects apoptosis and inflammatory signaling pathway. Proteinase 3 (PR3), Human Neutrophil interacts CD31/CD177, promotes transendothelial migration of neutrophils. Proteinase 3 (PR3), Human Neutrophil binds to neutrophil extracellular traps (NETs), degrades antimicrobial peptide precursors, participates in the immune defense. Proteinase 3 (PR3), Human Neutrophil degrades matrix proteins, activates proinflammatory cytokines, induces mucus production, thereby regulating inflammatory responses .

HY-156077

anti-TNBC agent-2	Apoptosis DNA/RNA Synthesis	Cancer
anti-TNBC agent-2 (3j) an anti-Triple negative breast cancer (TNBC) purine derivative. anti-TNBC agent-2 induces MDA-MB-231 cells apoptosis, and inhibits its migration and angiogenesis. anti-TNBC agent-2 inhibits tumor growth and metastasis and reduces the expression of Ki67 and CD31 protein in TNBC xenograft models. anti-TNBC agent-2 can be used for Triple negative breast cancer (TNBC) research .

HY-117991

DW10075	VEGFR	Cancer
DW10075 is a highly selective and orally active VEGFR inhibitor targeting the VEGF/VEGFR pathway. DW10075 selectively inhibits VEGFR-1, VEGFR-2, and VEGFR-3, but has no effect on FGFR and PDGFR. DW10075 inhibits VEGF-induced HUVEC proliferation, migration, and tube formation. And DW10075 inhibits angiogenesis in both the rat aortic ring model and the chick chorionic membrane model. DW10075 also exhibits antiproliferative activity against human cancer cell lines, with IC₅₀s of 2.2 μM and 22.2 μM against U87-MG human glioblastoma cells and A375 melanoma cells, respectively. In the nude mouse U87-MG xenograft tumor model, DW10075 (po) significantly inhibits tumor growth and reduces the expression of CD31 and Ki67 in tumor tissues.

HY-W777599

(±)-Naproxen-13C,d3-1 (Rac)-Naproxen-¹³C,d₃-1	Isotope-Labeled Compounds	Others
(±)-Naproxen- ¹³C,d₃-1 ((Rac)-Naproxen- ¹³C,d₃-1) is ¹³C and deuterium labeled (±)-Naproxen .

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-115349

Neamine tetrahydrochloride	Antibiotic Bacterial	Infection Neurological Disease Cancer
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .

HY-N7449

Neamine	Antibiotic Bacterial	Infection Cardiovascular Disease Neurological Disease Cancer
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities .

Cat. No.	Product Name	Target	Research Area

HY-P3444

*CD31* PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P3325

P8RI D-P8RI	VEGFR	Inflammation/Immunology
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a *CD31* agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

Cat. No.	Product Name	Target	Research Area

HY-P990277

*Anti-Mouse CD31/PECAM-1 Antibody (390)*	Transmembrane Glycoprotein	Others
Anti-Mouse CD31/PECAM-1 Antibody (390) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD31/PECAM-1.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7449

Neamine	Infection Cardiovascular Disease Classification of Application Fields Disease Research Fields	Antibiotic Bacterial
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities .

Species:	Human (3) Mouse (1) Cynomolgus (1)
Tag:	His (3) Tag Free (1) Fc (1)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P72892

	CD31/PECAM-1 Protein, Human 1 Publications Verification Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; PECA1; CD31	Human	HEK293
	CD31/PECAM-1 Protein, a pivotal cell adhesion molecule, is essential for leukocyte transendothelial migration (TEM) in most inflammatory conditions. PECAM1 modulates bradykinin receptor BDKRB2 activation and regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Signaling through PECAM-1 leads to the activation of neutrophils, monocytes and leukocytes. CD31/PECAM-1 Protein, Human is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with tag free.

HY-P72737

	CD31/PECAM-1 Protein, Mouse (HEK293, His) Platelet endothelial cell adhesion molecule; PECAM-1; CD31; Pecam	Mouse	HEK293
	The CD31/PECAM-1 protein is a cell adhesion molecule critical for leukocyte transendothelial migration (TEM) under inflammatory conditions.CD31/PECAM-1 also regulates bradykinin receptor BDKRB2 activation and modulates ERK1/2 activation in endothelial cells.CD31/PECAM-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72490

	CD31/PECAM-1 Protein, Human (HEK293, His) Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1	Human	HEK293
	CD31/PECAM-1 Protein is a cell-cell adhesion protein that is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31/PECAM-1 Protein, Human (HEK293, His) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70988

	CD31/PECAM-1 Protein, Human (HEK293, Fc) Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1	Human	HEK293
	CD31/PECAM-1 is a cell-cell adhesion protein. CD31/PECAM-1 regulates the activation of the slow hormone receptor BDKRB2 in endothelial cells and the activation of ERK1/2 induced by hypertonic shock and induces susceptibility to atherosclerosis. CD31/PECAM-1 mediates adhesion to endothelial cells and regulates tumor growth by forming new endothelial cell tubes. CD31/PECAM-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700675

	CD31/PECAM-1 Protein, Cynomolgus (HEK293, His) PECAM-1; EndoCAM; PECA1; CD31; FLJ34100; FLJ58394; GPIIA'	Cynomolgus	HEK293
	The CD31/PECAM-1 protein is a cell adhesion molecule critical for leukocyte transendothelial migration (TEM) under inflammatory conditions. CD31/PECAM-1 also regulates bradykinin receptor BDKRB2 activation and modulates ERK1/2 activation in endothelial cells. CD31/PECAM-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD31/PECAM-1 Protein, Cynomolgus (HEK293, His) is 575 a.a., with molecular weight of 95-115 kDa.

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HY-W654064

Azithromycin-13C,d3-1
Azithromycin-13C,d3-1 is a deuterated labeled Azithromycin-13C,d3-1 .

HY-W777599

(±)-Naproxen-13C,d3-1
(±)-Naproxen- ¹³C,d₃-1 ((Rac)-Naproxen- ¹³C,d₃-1) is ¹³C and deuterium labeled (±)-Naproxen .

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80599

	CD31 Antibody (YA806) Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD antigen CD31	WB, ICC/IF, IF-Tissue, mIHC	Human, Mouse
	CD31 Antibody (YA806) is a non-conjugated and Mouse origined monoclonal antibody about 83 kDa, targeting to CD31 (2D3). It can be used for WB, IF-Cell, IF-Tissue, IHC-P, mIHC assays with tag free, in the background of Human, Mouse.

HY-P80447

	CD31 Antibody 1 Publications Verification Adhesion molecule antibody; CD31 antibody; CD31 antigen antibody; CD31 EndoCAM antibody; EndoCAM antibody; FLJ34100 antibody; FLJ58394 antibody; GPIIA antibody; GPIIA' antibody; PECA1 antibody; PECA1_HUMAN antibody; Pecam 1 antibody; PECAM 1 CD31 EndoCAM antibody; PECAM antibody; PECAM-1 antibody; Pecam1 antibody; Platelet and endothelial cell adhesion molecule 1 antibody; Platelet endothelial cell adhesion molecule antibody; Platelet/endothelial cell adhesion molecule 1 antibody;	WB, IHC-P, ICC/IF, IP, FC	Human
	CD31 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to CD31. It can be used for WB,IHC-P,FC,IP,IF assays with tag free, in the background of Human.

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CD31

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