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Results for "

CETP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CETP (12) PCSK9 (2) Small Interfering RNA (siRNA) (1) Thrombin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (9) Endocrinology (1) Inflammation/Immunology (1) Metabolic Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Targets Recommended: CETP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12089

Torcetrapib CP-529414	CETP	Endocrinology
Torcetrapib (CP-529414) is a selective, potent cholesteryl ester transfer protein (CETP) inhibitor. A typical inhibition curve for whole human plasma, having a CETP concentration of 37 nM .

HY-13327

Evacetrapib 2 Publications Verification LY2484595	CETP	Cardiovascular Disease
Evacetrapib is a potent and selective of *CETP* inhibitor, which inhibits human recombinant CETP protein (IC₅₀ 5.5 nM) and CETP activity in human plasma (IC₅₀ 36 nM) in vitro.

HY-14950

Dalcetrapib JTT-705; RO4607381	CETP	Cardiovascular Disease Cancer
Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC₅₀s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively .

HY-12090

Anacetrapib 3 Publications Verification MK-0859	PCSK9	Cardiovascular Disease
Anacetrapib is a potent *CETP* inhibitor, with IC₅₀s of 7.9±2.5 nM and 11.8±1.9 nM for rhCETP and C13S CETP mutant, respectively.

HY-116078

CKD-519	CETP	Cardiovascular Disease
CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor, which inhibits CETP-mediated transfer of cholesteryl ester in human serum with an IC₅₀ of 2.3 nM .

HY-142643

CETP-IN-4	CETP	Metabolic Disease
CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.

HY-128338

CETP-IN-3	CETP	Cardiovascular Disease
CETP-IN-3 (Compound 13) is an small molecule inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. CETP-IN-3 for the CETP inhibitory activity in the scintillation proximity (SPA) and whole plasma assay (WPA) with IC₅₀s of 0.002 μM and 0.06 μM, respectively .

HY-RS02549

CETP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CETP Human Pre-designed siRNA Set A contains three designed siRNAs for CETP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CETP Human Pre-designed siRNA Set A CETP Human Pre-designed siRNA Set A

HY-19614

BMS-795311	CETP	Cardiovascular Disease
BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC₅₀s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively .

HY-107997

TAP311	CETP	Cardiovascular Disease
TAP311 is a cholesteryl ester transfer protein (CETP) inhibitor with an IC₅₀ of 62 nM .

HY-18778

Obicetrapib TA-8995; DEZ-001	CETP	Metabolic Disease
TA-8995 is a new and selective cholesteryl ester transfer protein (CETP) inhibitor.

HY-123039

CP-532623	CETP	Metabolic Disease
CP-532623 is a *CETP* inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties .

HY-N8353

Stachybotramide	Others	Metabolic Disease
Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL .

HY-123550

Rosenonolactone	Thrombin CETP	Inflammation/Immunology
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein .

HY-132303

MK-8262	CETP	Cardiovascular Disease Metabolic Disease
MK-8262 is an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor with an IC₅₀ of 53 nM and a log D of 5.3. MK-8262, a bistrifluoromethyl analogue, has the potential for coronary heart disease (CHD) correlated high-density lipoprotein (HDL) and low-density lipoprotein (LDL) research .

HY-P9928

Alirocumab 1 Publications Verification REGN 727; SAR 236553	PCSK9	Cardiovascular Disease Cancer
Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia .

Cat. No.	Product Name	Target	Research Area

HY-P9928

Alirocumab 1 Publications Verification REGN 727; SAR 236553	PCSK9	Cardiovascular Disease Cancer
Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P9928

Alirocumab 1 Publications Verification REGN 727; SAR 236553	Classification of Application Fields Disease Research Fields Cancer	PCSK9
Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia .

HY-N8353

Stachybotramide	Structural Classification Natural Products Microorganisms Source classification	Others
Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL .

HY-123550

Rosenonolactone	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Thrombin CETP
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83236

	CETP Antibody (YA2981) BPIFF; HDLCQ10; CETP; Lipid transfer protein I; Cholesteryl ester transfer protein	WB, IP	Human
	CETP Antibody (YA2981) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2981), targeting CETP, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). CETP Antibody (YA2981) can be used for WB, IP experiment in human background.

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CETP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CETP Human Pre-designed siRNA Set A contains three designed siRNAs for CETP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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CETP

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