CHD-1

By Targets:	Apoptosis (1) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) Mitophagy (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CHD1Li 6.11	DNA/RNA Synthesis	Cancer
CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC₅₀=3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties ^[1].

*CHD-1*	Mitophagy Apoptosis	Cancer
CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo ^[1].

CHD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHD1 Human Pre-designed siRNA Set A CHD1 Human Pre-designed siRNA Set A

Chd1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Chd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chd1 Mouse Pre-designed siRNA Set A Chd1 Mouse Pre-designed siRNA Set A

Chd1l Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Chd1l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chd1l Mouse Pre-designed siRNA Set A Chd1l Mouse Pre-designed siRNA Set A

CHD1L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHD1L Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHD1L Human Pre-designed siRNA Set A CHD1L Human Pre-designed siRNA Set A

UNC10142	Epigenetic Reader Domain	Cancer
UNC10142 (Compound 44) is a first-in-class small molecule antagonist of *CHD1* that binds with an IC₅₀ value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells ^[1].

Cat. No.	Compare	Product Name	Species	Source

	CHD1L Protein, Human (His-SUMO) ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; CHD1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FLJ22530	Human	E. coli
	CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of CHD1L Protein, Human (His-SUMO) is 194 a.a., with molecular weight of ~37.3 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

	CHD1L Antibody (YA2236) ALC1; CHD1l; CHDL	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	CHD1L Antibody (YA2236) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2236), targeting CHD1L, with a predicted molecular weight of 101 kDa (observed band size: 101 kDa). CHD1L Antibody (YA2236) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.

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Cat. No.	Product Name		Classification

CHD1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chd1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Chd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chd1l Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Chd1l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHD1L Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CHD1L Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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