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CK2 kinase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) Adenosine Kinase (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (4) Autophagy (5) c-Kit (1) Casein Kinase (24) CDK (1) Checkpoint Kinase (Chk) (1) DAPK (1) DNA-PK (1) DYRK (2) EGFR (1) Epigenetic Reader Domain (1) ERK (1) Isotope-Labeled Compounds (1) PI3K (2) Pim (3) SARS-CoV (3) Trk Receptor (1) Wnt (1)
By Research Areas:	Cancer (26) Infection (3) Inflammation/Immunology (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15535

DMAT 4 Publications Verification CK2 Inhibitor; Casein kinase II Inhibitor	Casein Kinase	Cancer
DMAT is a potent and specific CK2 inhibitor with an IC₅₀ value of 130 nM.

HY-148328

CK2-IN-4	Casein Kinase	Infection Inflammation/Immunology Cancer
CK2-IN-4 (compound 5) is a protein kinase (CK2) inhibitor (IC₅₀=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis .

HY-110052

TBCA	Casein Kinase	Cancer
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases .

HY-12570

CK2-IN-9	Casein Kinase Wnt	Cancer
CK2-IN-9 is a potent and selective inhibitor of **CK2 kinase with an IC₅₀** of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC₅₀ of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat .

HY-153788

CK2-IN-7	Casein Kinase	Cancer
CK2-IN-7 (compound 2) is an inhibitor of *casein kinase* 2** (CK2). CK2-IN-7 shows synergistic effect with structurally distinct CK2 chemical probe: SGC-CK2-1, against cancer .

HY-143461

CK2 inhibitor 3	Casein Kinase	Cancer
CK2 inhibitor 3 is a potent *CK2* inhibitor with IC₅₀ value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases .

HY-118403

CK2-IN-12	Casein Kinase	Infection Inflammation/Immunology Cancer
CK2-IN-12 (Compound 39) is an inhibitor for protein kinase CK2 with an IC₅₀ of 0.8 μM .

HY-148763

CK2-IN-6	Casein Kinase	Inflammation/Immunology Cancer
CK2-IN-6 is a potent protein kinase *CK2* inhibitor that can be used in the study of cancer as well as other kinase-related conditions, including inflammation, pain and certain immune diseases .

HY-135816

CK2/PIM1-IN-1	Casein Kinase Pim	Inflammation/Immunology Cancer
CK2/PIM1-IN-1 is an inhibitor of *CK2* and PIM1, with IC₅₀s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders .

HY-103384

TMCB	Casein Kinase	Cancer
TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct K_i values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively .

HY-145260

BRD4/CK2-IN-1	Epigenetic Reader Domain Casein Kinase Apoptosis Autophagy	Cancer
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of *BRD4/CK2* (bromodomain-containing protein 4/casein kinase 2), with IC₅₀s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)

HY-108606

PI-828 1 Publications Verification	PI3K Casein Kinase	Cancer
PI-828 is a dual PI3K and *casein kinase* 2** (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, *CK2, and CK2α2* in lipid kinase assay, respectively .

HY-135906

CK2/ERK8-IN-1	Casein Kinase ERK Pim DYRK Apoptosis	Cancer
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (K_i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC₅₀s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (*homeodomain-interacting protein kinase* 2), and DYRK1A with K_i*s of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic* efficacy .

HY-117332

IQA CGP-029482	Casein Kinase	Cancer
IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor .

HY-W042648

4,5,6,7-Tetrabromo-1H-benzimidazole	Casein Kinase	Others
4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive *CK2* (casein kinase 2) inhibitor .

HY-124833

Quinalizarin	Casein Kinase	Cancer
Quinalizarin is a potent, selective and cell-permeable protein kinase *CK2* inhibitor with an K_i of ~50 nM and an IC₅₀ of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells .

HY-162078

Antiproliferative agent-46	Casein Kinase	Cancer
Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC₅₀ value of 5.75 μM on the U87 cell line .

HY-156816

ON 108600	Casein Kinase DYRK	Cancer
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity .

HY-15424

5-Iodotubercidin 5+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-115519

(E/Z)-GO289 1 Publications Verification	Casein Kinase	Cancer
(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .

HY-124321

Metralindole hydrochloride	Others	Cancer
Metralindole hydrochloride is a significant inhibitor of human cyclin-dependent kinase-2 and Human Protein Kinase CK2 Holoenzyme, exhibiting high binding affinity in the context of lung cancer treatment. Metralindole hydrochloride demonstrates promising docking scores and molecular dynamics stability, indicating its potential efficacy as a therapeutic agent against non-small cell lung cancer. Metralindole hydrochloride further shows excellent pharmacokinetic properties, including outstanding solubility and bioavailability, making it a compelling candidate for future experimental validation in lung cancer therapy.

HY-14393

Emodin 20+ Cited Publications Frangula emodin	SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-10108

LY294002 Maximum Cited Publications 779 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis Autophagy	Infection Cancer
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits *CK2* with an IC₅₀ of 98 nM . LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4?μM. LY294002 is an apoptosis activator .

HY-14393S

Emodin-d4 Frangula emodin-d₄	Isotope-Labeled Compounds SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-14393R

Emodin (Standard) Frangula emodin (Standard)	SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-149006

CK156	DAPK	Inflammation/Immunology Cancer
CK156 is a highly selective death-associated protein kinase (DAPK) inhibitor with IC₅₀s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases .

HY-156470

Multi-kinase-IN-6	Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis	Cancer
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, *CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC₅₀* values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14393

Emodin 20+ Cited Publications Frangula emodin	Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14393R

Emodin (Standard) Frangula emodin (Standard)	Quinones Structural Classification Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Cat. No.	Product Name	Chemical Structure

HY-14393S

Emodin-d4
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

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