CLDN18

By Targets:	CD3 (2) CD47 (1) Claudin (2) Small Interfering RNA (siRNA) (2) TNF Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (6)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99350

Gresonitamab AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-RS02768

CLDN18 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLDN18 Human Pre-designed siRNA Set A contains three designed siRNAs for CLDN18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLDN18 Human Pre-designed siRNA Set A CLDN18 Human Pre-designed siRNA Set A

HY-RS18701

Cldn18 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cldn18 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cldn18 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cldn18 Mouse Pre-designed siRNA Set A Cldn18 Mouse Pre-designed siRNA Set A

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human *CLDN18* (claudin-18). Garetatug specifically binds to *CLDN18*, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and *CLDN18* (claudin 18). Tixentamig is promising for research of cancers .

HY-P990742

Givastomig	TNF Receptor	Inflammation/Immunology
Givastomig is an anti-TNFRSF9/CLDN18 monoclonal antibody .

HY-P991027

Spevatamig	CD47	Inflammation/Immunology
HY-P991027 is an *CD47/CLDN18*-targeting (H-γ1_L-κ)_(H-γ1_L-κ) type bispecific antibody .

Cat. No.	Product Name	Target	Research Area

HY-P99350

Gresonitamab AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human *CLDN18* (claudin-18). Garetatug specifically binds to *CLDN18*, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and *CLDN18* (claudin 18). Tixentamig is promising for research of cancers .

HY-P990742

Givastomig	TNF Receptor	Inflammation/Immunology
Givastomig is an anti-TNFRSF9/CLDN18 monoclonal antibody .

HY-P991026

Sonesitatug	Inhibitory Antibodies	Inflammation/Immunology
HY-P991026 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991013

Omectatug	Inhibitory Antibodies	Inflammation/Immunology
HY-P991013 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990979

Ciletatug	Inhibitory Antibodies	Inflammation/Immunology
HY-P990979 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990946

Tecotabart	Inhibitory Antibodies	Inflammation/Immunology
HY-P990946 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991027

Spevatamig	CD47	Inflammation/Immunology
HY-P991027 is an *CD47/CLDN18*-targeting (H-γ1_L-κ)_(H-γ1_L-κ) type bispecific antibody .

Species:	Human (6) Mouse (1) Cynomolgus (1)
Tag:	His (5) mCherry (1) Tag Free (2)
Source:	HEK293 (6) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70701

	*Claudin-18/CLDN18.2 Protein, Human (His)* Claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by E. coli , with N-8*His labeled tag. The total length of Claudin-18/CLDN18.2 Protein, Human (His) is 49 a.a., with molecular weight of ~18.0 kDa.

HY-P70045

	*Claudin-18/CLDN18.1 Protein, Human (His)* rHuClaudin-18/CLDN18, His; Claudin-18; CLDN18	Human	E. coli
	CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.1 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.1 protein, expressed by E. coli , with N-8*His labeled tag. The total length of Claudin-18/CLDN18.1 Protein, Human (His) is 49 a.a., with molecular weight of ~18.0 kDa.

HY-P78368

	*Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700404

	*Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His)* rHuClaudin-18/CLDN18, His; Claudin-18; CLDN18	Mouse	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P78105

	*Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) is available in solution form, no concentration information, recommended only for SPR analysis. HY-P78368 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700403

	*Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P700440

	*Claudin-18/CLDN18.2 Protein-VLP, Macaca fascicularis (HEK293, His)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Cynomolgus	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Macaca fascicularis (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P702247

	*Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry)* Claudin-18	Human	HEK293
	Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81773

	Claudin 18.2 Antibody CLDN 18.2,Claudin 18.2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Claudin 18.2 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Claudin 18.2, with a predicted molecular weight of 28 kDa. Claudin 18.2 Antibody can be used for WB, IHC-P, ICC/IF, FC experiments in human, mouse, rat backgrounds.

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Cat. No.	Product Name		Classification

HY-RS02768

CLDN18 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CLDN18 Human Pre-designed siRNA Set A contains three designed siRNAs for CLDN18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18701

Cldn18 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cldn18 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cldn18 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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