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Results for "

COIL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) FGFR (2) G Protein-coupled Receptor Kinase (GRK) (1) HIV (2) HIV Protease (1) IGF-1R (1) ROCK (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (2) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10996A

KHS101 hydrochloride	FGFR	Neurological Disease Cancer
KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3).

HY-18990

GSK180736A 5+ Cited Publications	ROCK	Cardiovascular Disease
GSK180736A is potent *Rho-associated coiled-coil* kinase 1 (ROCK1) inhibitor with an IC₅₀ of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC₅₀** of 0.77 μM.

HY-135960

BO-264	FGFR Apoptosis	Cancer
BO-264 is a highly potent and orally active *transforming acidic coiled-coil* 3 (TACC3) inhibitor with an IC₅₀ of 188 nM and a K_d of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis**. BO-264 has broad-spectrum antitumor activity .

HY-148808

Zelasudil RXC007	ROCK	Cancer
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .

HY-RS02958

COIL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
COIL Human Pre-designed siRNA Set A contains three designed siRNAs for COIL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

COIL Human Pre-designed siRNA Set A COIL Human Pre-designed siRNA Set A

HY-118837

WF-536	ROCK	Cancer
WF-536 is an orally active inhibitor of *Rho-associated coiled-coil-containing protein kinase (ROCK)*. WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer .

HY-P10820

N36Mut(e,g)	HIV	Infection
N36Mut(e,g) is a gp41-targeted HIV fusion peptide inhibitor. N36Mut(e,g) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pre-hairpin intermediate to form heterotrimers .

HY-118046

GSK2163632A	G Protein-coupled Receptor Kinase (GRK) ROCK IGF-1R	Cardiovascular Disease
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).

HY-150536

EP39	HIV HIV Protease	Infection
EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity .

Cat. No.	Product Name	Target	Research Area

HY-P10820

N36Mut(e,g)	HIV	Infection
N36Mut(e,g) is a gp41-targeted HIV fusion peptide inhibitor. N36Mut(e,g) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pre-hairpin intermediate to form heterotrimers .

Species:	Human (5)
Tag:	His (4) Tag Free (1)
Source:	HEK293 (2) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73708

	PIST Protein, Human (His) Golgi-associated PDZ and COILed-COIL motif-containing protein; PIST; GOPC; CAL; FIG	Human	E. coli
	PIST (PDZ domain-containing protein that interacts with Stx6) is critical in intracellular protein trafficking and degradation. It modulates CFTR chloride currents and acid-induced ASIC3 currents, thereby potentially regulating their cell surface expression. PIST Protein, Human (His) is the recombinant human-derived PIST protein, expressed by E. coli , with N-His labeled tag.

HY-P76768

	CCDC47 Protein, Human (HEK293, His) PAT complex subunit CCDC47; Calumin; COILed-COIL domain-containing protein 47	Human	HEK293
	The CCDC47 protein is an important component of the multichannel translocon (MPT) complex, which facilitates the insertion of multichannel membrane proteins into lipid bilayers. It blocks the lateral gate of the SEC61 complex, allowing insertion of subsequent transmembrane domains. CCDC47 Protein, Human (HEK293, His) is the recombinant human-derived CCDC47 protein, expressed by HEK293 , with C-His labeled tag.

HY-P701769

	ROCK1 Protein, Human (Sf9) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; COILed-COIL-containing protein kinase 1; Rho-associated; COILed-COIL-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with tag free. The total length of ROCK1 Protein, Human (Sf9) is 410 a.a., .

HY-P701770

	ROCK1 Protein, Human (Sf9, His) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; COILed-COIL-containing protein kinase 1; Rho-associated; COILed-COIL-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9, His) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of ROCK1 Protein, Human (Sf9, His) is 410 a.a., .

HY-P7762

	CCDC134 Protein, Human (HEK293, His) rHuCCDC134, His; COILed-COIL domain-containing protein 134; CCDC134	Human	HEK293
	CCDC134 Protein, Human (HEK293, His) is a cytokine-like molecule that exerts antitumor effects by augmenting CD8⁺ T-cell mediated immunity.

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HY-P83176

	TACC3 Antibody (YA2921) TACC3; ERIC1; Transforming acidic COILed-COIL-containing protein 3; ERIC-1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	TACC3 Antibody (YA2921) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2921), targeting TACC3, with a predicted molecular weight of 90 kDa (observed band size: 140 kDa). TACC3 Antibody (YA2921) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82787

	Coilin Antibody (YA2532) CLN80; COIL; COILin; COILin p80	WB	Human
	Coilin Antibody (YA2532) is a non-conjugated IgG antibody, targeting Coilin, with a predicted molecular weight of 63 kDa (observed band size: 80 kDa). Coilin Antibody (YA2532) can be used for WB experiment in human background.

HY-P83257

	CC2D1A Antibody (YA3002) COILed COIL and C2 domain containing 1A; FREUD 1; Freud 1/Aki1; MRT3	WB, ICC/IF, FC	Human, Mouse, Rat
	CC2D1A Antibody (YA3002) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3002), targeting CC2D1A, with a predicted molecular weight of 104 kDa (observed band size: 130 kDa). CC2D1A Antibody (YA3002) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.

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COIL Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
COIL Human Pre-designed siRNA Set A contains three designed siRNAs for COIL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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