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CRMP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (3) HIV (1) iGluR (1) Sodium Channel (1)
By Research Areas:	Infection (1) Inflammation/Immunology (3) Neurological Disease (2)

5

Inhibitors & Agonists

3

Peptides

1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CBD3063	Calcium Channel	Inflammation/Immunology
CBD3063 is a selective modulator of collapsin response mediator protein 2 (CRMP2). CBD3063 uncouples Cav2.2 from CRMP2. CBD3063 reverses neuropathic and inflammatory pain by reducing membrane expression of CaV2.2 ^[2].

AZ194	Sodium Channel	Neurological Disease
AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC₅₀=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects .

TAT-CBD3	HIV iGluR	Infection Inflammation/Immunology
TAT-CBD3, a 15-amino acid peptide from CRMP2, fused to the TAT cell-penetrating motif of the HIV-1 protein, disrupts CRMP2-NMDAR interaction without change in NMDAR localization .

Myr-TAT-CBD3	Calcium Channel	Inflammation/Immunology
Myr-TAT-CBD3 is *CRMP2-CaV2.2* interaction inhibitor. Myr-tat-CBD3 can significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity induced in a rat model of postoperative pain. Myr-TAT-CBD3 can be used to study inflammation and postoperative pain .

TAT-CBD3A6K	Calcium Channel	Neurological Disease
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function ^[2].

Cat. No.	Product Name	Target	Research Area

TAT-CBD3	HIV iGluR	Infection Inflammation/Immunology
TAT-CBD3, a 15-amino acid peptide from CRMP2, fused to the TAT cell-penetrating motif of the HIV-1 protein, disrupts CRMP2-NMDAR interaction without change in NMDAR localization .

Myr-TAT-CBD3	Calcium Channel	Inflammation/Immunology
Myr-TAT-CBD3 is *CRMP2-CaV2.2* interaction inhibitor. Myr-tat-CBD3 can significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity induced in a rat model of postoperative pain. Myr-TAT-CBD3 can be used to study inflammation and postoperative pain .

TAT-CBD3A6K	Calcium Channel	Neurological Disease
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function ^[2].

Cat. No.	Compare	Product Name	Species	Source

	DPYSL2 Protein, Human (P.pastoris, His) Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2	Human	P. pastoris
	DPYSL2 protein plays a crucial role in neuronal development, polarity, axon growth, guidance, growth cone collapse, and cell migration. It is essential for signaling by class 3 semaphorins and cytoskeleton remodeling. DPYSL2 forms homotetramers and heterotetramers with CRMP1, DPYSL3, DPYSL4, or DPYSL5. It interacts with CYFIP1/SRA1, HTR4, CLN6, and MICALL1, highlighting its diverse functions and interactions in cellular processes. DPYSL2 Protein, Human (P.pastoris, His) is the recombinant human-derived DPYSL2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of DPYSL2 Protein, Human (P.pastoris, His) is 572 a.a., with molecular weight of ~64.3 kDa.

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	CRMP2 Antibody (YA3370) DRP2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2; DPYSL2; CRMP2; ULIP2; Musunc33; TOAD64	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	CRMP2 Antibody (YA3370) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3370), targeting CRMP2, with a predicted molecular weight of 62 kDa. CRMP2 Antibody (YA3370) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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