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Results for "

Caspase-independent death

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103661
    BI-6C9
    1 Publications Verification

    		 Mitochondrial Metabolism Apoptosis Neurological Disease
    BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
    BI-6C9
  • HY-117433
    4-Hydroperoxy cyclophosphamide
    5 Publications Verification

    		 DNA Alkylator/Crosslinker Apoptosis Reactive Oxygen Species Drug Metabolite Inflammation/Immunology
    4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases .
    4-Hydroperoxy cyclophosphamide
  • HY-117200
    Necrostatin-7

    Nec-7

    		 Necroptosis Cancer
    Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase .
    Necrostatin-7
  • HY-113915
    Kuguaglycoside C

    		Apoptosis Neurological Disease Cancer
    Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .
    Kuguaglycoside C
  • HY-161661
    Anticancer agent 223

    		Others Cancer
    Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394)-resistant A2780 cells to cisplatin (HY-17394) treatment .
    Anticancer agent 223
  • HY-129765
    Thiobenzanilide 63T

    		Others Cancer
    Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells .
    Thiobenzanilide 63T

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