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Cathepsin B Substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (13) Ser/Thr Protease (1)
By Research Areas:	Cancer (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Targets Recommended: Cathepsin MARCKS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134434

Z-Arg-Arg-AMC hydrochloride	Cathepsin	Others
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .

HY-155667A

Z-Nle-Lys-Arg-AMC acetate	Cathepsin	Others
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4500

Z-Arg-Arg-pNA	Cathepsin	Others
Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity .

HY-118959

S2160 Bz-Phe-Val-Arg-pNA	Cathepsin	Others
S2160 is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B .

HY-155667

Z-Nle-Lys-Arg-AMC	Others	Others
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-P2498

**Cathepsin D and E FRET Substrate**	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4340

Arg-Arg-AMC	Cathepsin	Cancer
Arg-Arg-AMC is a highly selective substrate of *Cathepsin* B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .

HY-P4369

Z-Arg-Arg-AMC	Cathepsin	Others
Z-Arg-Arg-AMC is a selective substrate of cathepsin B .

HY-P4340A

Arg-Arg-AMC acetate	Cathepsin	Others
Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .

HY-158307

Z-Arg-Arg-βNA acetate	Cathepsin	Others
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .

HY-137841

L-Arginine-7-amido-4-methylcoumarin hydrochloride Arginine 4-methyl-7-coumarylamide hydrochloride	Cathepsin	Others
L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K Substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-D1523

Z-Arg-Arg-4MβNA triacetate	Cathepsin	Others
Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λ_ex = 355 nm, λ_em = 430 nm) .

Z-Arg-Arg-4MβNA triacetate	Fluorescent Dyes/Probes
Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λ_ex = 355 nm, λ_em = 430 nm) .

Cat. No.	Product Name	Type

HY-137841

L-Arginine-7-amido-4-methylcoumarin hydrochloride Arginine 4-methyl-7-coumarylamide hydrochloride	Enzyme Substrates
L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .

Cat. No.	Product Name	Target	Research Area

HY-134434

Z-Arg-Arg-AMC hydrochloride	Cathepsin	Others
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4340A

Arg-Arg-AMC acetate	Cathepsin	Others
Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .

HY-158307

Z-Arg-Arg-βNA acetate	Cathepsin	Others
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .

HY-P4500

Z-Arg-Arg-pNA	Cathepsin	Others
Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity .

HY-P4404

Abz-GIVRAK(Dnp)	Peptides	Others
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-P2498

**Cathepsin D and E FRET Substrate**	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4340

Arg-Arg-AMC	Cathepsin	Cancer
Arg-Arg-AMC is a highly selective substrate of *Cathepsin* B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .

HY-P4369

Z-Arg-Arg-AMC	Cathepsin	Others
Z-Arg-Arg-AMC is a selective substrate of cathepsin B .

HY-P4428

Z-Val-Lys-Met-AMC	Peptides	Others
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K Substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

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