2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. L-Arginine-7-amido-4-methylcoumarin hydrochloride

L-Arginine-7-amido-4-methylcoumarin hydrochloride  (Synonyms: Arginine 4-methyl-7-coumarylamide hydrochloride)

Cat. No.: HY-137841 Purity: 99.23%
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L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B.

For research use only. We do not sell to patients.

L-Arginine-7-amido-4-methylcoumarin hydrochloride Chemical Structure

L-Arginine-7-amido-4-methylcoumarin hydrochloride Chemical Structure

CAS No. : 69304-16-1

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5 mg USD 110 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

L-Arginine-7-amido-4-methylcoumarin hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

  • Purity & Documentation

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Description

L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B[1].

Molecular Weight

367.83

Formula

C16H22ClN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(NC([C@@H](N)CCCNC(N)=N)=O)C=C1O2)=CC2=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (135.93 mM; Need ultrasonic)

DMSO : 3.85 mg/mL (10.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7186 mL 13.5932 mL 27.1865 mL
5 mM 0.5437 mL 2.7186 mL 5.4373 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.7186 mL 13.5932 mL 27.1865 mL 67.9662 mL
5 mM 0.5437 mL 2.7186 mL 5.4373 mL 13.5932 mL
10 mM 0.2719 mL 1.3593 mL 2.7186 mL 6.7966 mL
H2O 15 mM 0.1812 mL 0.9062 mL 1.8124 mL 4.5311 mL
20 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3983 mL
25 mM 0.1087 mL 0.5437 mL 1.0875 mL 2.7186 mL
30 mM 0.0906 mL 0.4531 mL 0.9062 mL 2.2655 mL
40 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
50 mM 0.0544 mL 0.2719 mL 0.5437 mL 1.3593 mL
60 mM 0.0453 mL 0.2266 mL 0.4531 mL 1.1328 mL
80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
100 mM 0.0272 mL 0.1359 mL 0.2719 mL 0.6797 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Arginine-7-amido-4-methylcoumarin hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Arginine-7-amido-4-methylcoumarin69304-16-1Arginine 4-methyl-7-coumarylamideCathepsinCathepsin H SubstrateInhibitorinhibitorinhibit

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