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Coffee

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

28

Natural
Products

5

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W001663
    4'-Hydroxy-3'-methylacetophenone

    		Bacterial Infection
    4'-Hydroxy-3'-methylacetophenone, a phenolic volatile compound, is isolated from Hawaiian green coffee beans (Coffea Arabica L.). 4'-Hydroxy-3'-methylacetophenone has potent antioxidant activities. 4'-Hydroxy-3'-methylacetophenone also can be used to synthesize heterocyclic compounds which have antimycobacterial activity .
    4'-Hydroxy-3'-methylacetophenone
  • HY-N0464
    D-(-)-Quinic acid
    1 Publications Verification

    		 Endogenous Metabolite Infection Inflammation/Immunology
    D-(-)-Quinic acid is a cyclohexanecarboxylic acid and is implicated in the perceived acidity of coffee.
    D-(-)-Quinic acid
  • HY-113340
    2-Furoylglycine

    		Endogenous Metabolite Others
    2-Furoylglycine, a urinary metabolite in human, is a putative biomarker for coffee consumption .
    2-Furoylglycine
  • HY-W010608
    2-Methyltetrahydrofuran-3-one

    		Others Others
    2-Methyltetrahydrofuran-3-one is one of the volatile constituents of roasted coffee .
    2-Methyltetrahydrofuran-3-one
  • HY-113472
    N-Methyl-4-pyridone-3-carboxamide

    		Drug Metabolite Others
    N-Methyl-4-pyridone-3-carboxamide is a metabolite of coffee pyridines .
    N-Methyl-4-pyridone-3-carboxamide
  • HY-116056
    16-O-Methylcafestol

    		Others Others
    16-O-Methylcafestol is a derivative of cafestol that can be isolated from green coffee beans .
    16-O-Methylcafestol
  • HY-123528
    Kahweol oleate

    		Others Others
    Kahweol oleate is a diterpene and can be isolated from coffee .
    Kahweol oleate
  • HY-122270
    Kahweol stearate

    		Others Inflammation/Immunology Cancer
    Kahweol stearate is a diterpenoid ester found in coffee that exhibits anti-inflammatory, anticancer, and antiangiogenic activities .
    Kahweol stearate
  • HY-127098
    Kahweol linoleate

    		Others Others
    Kahweol linoleate is a diterpenoid ester, which found in coffee beans. Kahweol linoleate exhibits an impact on the aroma and taste of coffee .
    Kahweol linoleate
  • HY-N4241
    Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)-

    		Others Others
    Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)- (compound 5) is a endogenous ent-kaurane diterpene compound in green coffee beans, providing direct chemical indicators of low-quality coffee .
    Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)-
  • HY-N0464S
    Quinic acid-13C3

    		Isotope-Labeled Compounds Endogenous Metabolite Infection Inflammation/Immunology
    Quinic acid- 13C3 is the 13C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid is a cyclohexanecarboxylic acid and is implicated in the perceived acidity of coffee.
    Quinic acid-13C3
  • HY-N0464R
    D-(-)-Quinic acid (Standard)

    		Endogenous Metabolite Infection Inflammation/Immunology
    D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid is a cyclohexanecarboxylic acid and is implicated in the perceived acidity of coffee.
    D-(-)-Quinic acid (Standard)
  • HY-W010451
    1,2,4-Trihydroxybenzene

    		Calcium Channel Cardiovascular Disease
    1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca 2+ concentration in rat thymic lymphocytes .
    1,2,4-Trihydroxybenzene
  • HY-W017389
    Xanthine
    4 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
    Xanthine
  • HY-N0415S
    Trigonelline-d3 chloride

    Trigonelline-d3 hydrochloride

    		 Isotope-Labeled Compounds HSV Bacterial Fungal Infection Metabolic Disease Cancer
    Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
    Trigonelline-d3 chloride
  • HY-N6257
    Cafestol
    1 Publications Verification

    		 ERK PGE synthase COX NF-κB Inflammation/Immunology Cancer
    Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects .
    Cafestol
  • HY-N10044
    3-Feruloyl-4-caffeoylquinic acid

    		Others Others
    3-Feruloyl-4-caffeoylquinic acidis acaffeoyl, feruloyl quinic acidderivativeisolated fromroasted C.arabica .
    3-Feruloyl-4-caffeoylquinic acid
  • HY-W016278
    Gamma-undecalactone

    		Biochemical Assay Reagents Others
    Gamma-undecalactone consists of a five-membered dihydrofuran ring with an ester group and a heptyl chain. This compound has a fruity smell and is commonly used as a flavor additive in various food and beverage products such as coffee, tea and baked goods.
    Gamma-undecalactone
  • HY-Y1426
    2'-Hydroxyacetophenone

    o-Hydroxyacetophenone; o-Acetylphenol

    		 Others Others
    2'-Hydroxyacetophenone is found in alcoholic beverages. 2'-Hydroxyacetophenone is present in tomato, cassia, fried beef, rum, whiskey, cocoa, coffee and black tea. 2'-Hydroxyacetophenone is a flavouring ingredient. Building block in chemical synthesis.
    2'-Hydroxyacetophenone
  • HY-N6258
    Kahweol

    		AMPK Apoptosis Metabolic Disease
    Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
    Kahweol
  • HY-N6257R
    Cafestol (Standard)

    		ERK PGE synthase COX NF-κB Inflammation/Immunology Cancer
    Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects .
    Cafestol (Standard)
  • HY-Y0543
    5-Methylfurfural
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.
    5-Methylfurfural
  • HY-Y0949
    Methyl 2-furoate
    1 Publications Verification

    Methyl furan-2-carboxylate

    		 Endogenous Metabolite Others
    Methyl 2-furoate (Methyl furan-2-carboxylate) is a building block in chemical synthesis. A flavoring agent in food. Found in cranberries, guava fruits, raisins and other fruits. Also present in baked potato, roasted filberts, roasted peanut, tomatoes, coffee, cocoa, okra, etc.
    Methyl 2-furoate
  • HY-N6258R
    Kahweol (Standard)

    		AMPK Apoptosis Metabolic Disease
    Kahweol (Standard) is the analytical standard of Kahweol. This product is intended for research and analytical applications. Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
    Kahweol (Standard)
  • HY-N0264
    Ligustrazine
    Maximum Cited Publications
    6 Publications Verification

    Chuanxiongzine; Tetramethylpyrazine

    		 Apoptosis Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong) , is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats .
    Ligustrazine
  • HY-W012998
    2,3-Pentanedione

    		Others Others
    2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
    2,3-Pentanedione
  • HY-Y1426R
    2'-Hydroxyacetophenone (Standard)

    		Others Others
    2'-Hydroxyacetophenone (Standard) is the analytical standard of 2'-Hydroxyacetophenone. This product is intended for research and analytical applications. 2'-Hydroxyacetophenone is found in alcoholic beverages. 2'-Hydroxyacetophenone is present in tomato, cassia, fried beef, rum, whiskey, cocoa, coffee and black tea. 2'-Hydroxyacetophenone is a flavouring ingredient. Building block in chemical synthesis.
    2'-Hydroxyacetophenone (Standard)
  • HY-W008566
    Norharmane

    Norharman; β-Carboline

    		 Monoamine Oxidase Endogenous Metabolite Infection Neurological Disease Cancer
    Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
    Norharmane
  • HY-W008566R
    Norharmane (Standard)

    		Monoamine Oxidase Endogenous Metabolite Infection Neurological Disease Cancer
    Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
    Norharmane (Standard)
  • HY-D2264
    Caffeine orange

    		Fluorescent Dye Others
    Caffeine orange (Compound 1) is an aqueous-phase fluorescence turn-on sensor for caffeine that is highly selective to caffeine. Caffeine orange makes caffeinated coffee appear orange when exposed to 532 nM of green excitation light. Caffeine orange has excellent photophysical properties such as high extinction coefficient, high light stability and narrow emission bandwidth, which can be used in the research of caffeine detection devices 。
    Caffeine orange
  • HY-Y0543R
    5-Methylfurfural (Standard)

    		Biochemical Assay Reagents Others
    5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.
    5-Methylfurfural (Standard)
  • HY-158820
    Cosdosiran

    QPI-1007

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran
  • HY-158820A
    Cosdosiran sodium

    QPI-1007 sodium

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran sodium
  • HY-E70364
    IgdE protease

    		Biochemical Assay Reagents Inflammation/Immunology
    IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
    IgdE protease
  • HY-N0264R
    Ligustrazine (Standard)

    		Apoptosis Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Ligustrazine (Standard) is the analytical standard of Ligustrazine. This product is intended for research and analytical applications. Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong) , is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats .
    Ligustrazine (Standard)
  • HY-W017389R
    Xanthine (Standard)

    		Endogenous Metabolite Inflammation/Immunology
    Xanthine (Standard) is the analytical standard of Xanthine. This product is intended for research and analytical applications. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation . In Vitro: A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.
    Xanthine (Standard)
  • HY-W012998S
    2,3-Pentanedione-d5

    		Isotope-Labeled Compounds Others
    2,3-Pentanedione-d5 is the deuterium labeled 2,3-Pentanedione[1]. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans[2].
    2,3-Pentanedione-d5
  • HY-N6745S
    Citreoviridin-13C23

    		Na+/K+ ATPase Apoptosis Isotope-Labeled Compounds Infection
    Citreoviridin- 13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
    Citreoviridin-13C23
  • HY-W050154S
    Kojic acid-13C6

    		Parasite Isotope-Labeled Compounds Infection
    Kojic acid- 13C6 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
    Kojic acid-13C6
  • HY-W012998R
    2,3-Pentanedione (Standard)

    		Others Others
    2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
    2,3-Pentanedione (Standard)
  • HY-N7210
    Kahweol acetate

    		Apoptosis Cancer
    Kahweol acetate, a bioactive compound found in coffee, has been identified for its potent anti-cancer properties, particularly in inhibiting the proliferation and migration of prostate cancer cells. Alongside cafestol, it shows dose-dependent effects in suppressing tumor growth and metastasis in both in vitro and in vivo studies. Mechanistically, kahweol acetate and cafestol induce apoptosis, inhibit epithelial-mesenchymal transition, and reduce androgen receptor activity, especially in androgen receptor-positive cells. They also downregulate chemokine receptors CCR2 and CCR5, crucial for cancer progression, without altering their ligand levels. These findings suggest that kahweol acetate, in combination with cafestol, may serve as promising therapeutic agents against prostate cancer .
    Kahweol acetate

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