Ligustrazine-d₁₂  (Synonyms: Chuanxiongzine-d₁₂; Tetramethylpyrazine-d₁₂)

Ligustrazine-d₁₂ (Chuanxiongzine-d₁₂) is deuterium labeled Ligustrazine. Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong)^[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats^[2][3][4].

148.27

C₈D₁₂N₂

65127-74-4

1124-11-4

[2H]C(C1=C(C([2H])([2H])[2H])N=C(C([2H])([2H])[2H])C(C([2H])([2H])[2H])=N1)([2H])[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638.  [Content Brief]

  [3]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6.  [Content Brief]

  [4]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.  [Content Brief]