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Cyclic Pifithrin-α

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16702A
    Pifithrin-β hydrobromide
    Maximum Cited Publications
    15 Publications Verification

    PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide

    		 MDM-2/p53 Ferroptosis Cancer
    Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
    Pifithrin-β hydrobromide
  • HY-123076
    Pifithrin-α, p-Nitro, Cyclic
    4 Publications Verification

    PFN-α

    		 MDM-2/p53 Neurological Disease
    Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue .
    Pifithrin-α, p-Nitro, Cyclic
  • HY-16702
    Pifithrin-β

    PFT β; Cyclic Pifithrin-α

    		 MDM-2/p53 Cancer
    Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
    Pifithrin-β