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D-Xylulose

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (2) Biochemical Assay Reagents (2) Endogenous Metabolite (6) Isotope-Labeled Compounds (3) Parasite (7) Transketolase (1)
By Research Areas:	Infection (9) Metabolic Disease (6)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010256

*D-Xylulose*	Endogenous Metabolite	Metabolic Disease
D-xylulose is a precursor of the pentiol D-arabitol.

HY-W010256S3

D-Xylulose-13C5	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Xylulose-13C5 is ¹³C labeled D-Xylulose. D-xylulose is the precursor of arabinitol .

HY-E70308

Glucose isomerase (immobilized)	Endogenous Metabolite	Others
Glucose isomerase (immobilized) is a glucose isomerase that catalyzes the reversible isomerization of D-glucose and D-xylose into D-fructose and D-xylulose, respectively. Glucose isomerase (immobilized) is thermally stable and can be used to produce fructose syrup at high temperatures above 90°C. Glucose isomerase (immobilized) is widely distributed in prokaryotes .

HY-W712327

D-Xylulose 5-phosphate sodium	Biochemical Assay Reagents	Others
D-Xylulose 5-phosphate (sodium) is a pentose phosphate ester and an essential intermediate metabolite in the pentose phosphate pathway (PPP) and the non-oxidative phase of the pentose phosphate pathway. D-xylulose-5-phosphate can be efficiently synthesized through the phosphorylation of D-xylulose catalyzed by D-xylulokinase (XKS1 from Saccharomyces cerevisiae), with ATP regeneration facilitated by the phosphoenolpyruvate (PEP)/pyruvate kinase (PK) system .

HY-W587841

D-Xylulose 5-phosphate	Transketolase	Metabolic Disease
D-Xylulose 5-phosphate is the enzymatic product of transketolase .

HY-W010256S

D-Xylulose-1-13C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Xylulose-1- ¹³C is the ¹³C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].

HY-W010256S1

D-Xylulose-2-13C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Xylulose-2- ¹³C is the ¹³C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].

HY-W717654

*1-Deoxy-D-xylulose* 5-phosphate**	Endogenous Metabolite	Metabolic Disease
1-Deoxy-D-xylulose 5-phosphate (DXP) is a biosynthetic precursor to isoprenoids, thiamin (vitamin B1), and pyridoxol (vitamin B6). 1-Deoxy-D-xylulose 5-phosphate can be utilized in metabolic research .

HY-W415921

1-Deoxy-D-threo-pentulose	Biochemical Assay Reagents
1-Deoxy-D-threo-pentulose is a derivative of D-xylulose, which has application activity in the study of mevalonate pathway. 1-Deoxy-D-threo-pentulose is widely used to explore the mechanism of cell metabolism. 1-Deoxy-D-threo-pentulose has important experimental value in biochemical research.

HY-161406

DXPS-IN-1	Bacterial	Infection
DXPS-IN-1 (Compound 8) is an inhibitor of 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) with a K_i value of 2.9 nM against EcDXPS. DXPS-IN-1 exhibits antibacterial activity .

HY-W795264

FR900098	Parasite	Infection
FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .

HY-149882

Antimalarial agent 27	Parasite	Infection
Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC₅₀=0.37 μM). Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC₅₀=0.11 μM) .

HY-122817

FR900098 sodium	Antibiotic Parasite	Infection
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .

HY-158818

DXR-IN-2	Parasite	Infection
DXR-IN-2 is a *1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR)* inhibitor and an antimalarial agent (IC₅₀: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR .

HY-168447

D-PheTrAP	Bacterial	Infection
D-PheTrAP is a bisubstrate analog inhibitor of *1-Deoxy-d-xylulose* 5-phosphate synthase (DXPS)*. D-PheTrAP inhibits Escherichia coli* DXPS (EcDXPS) and Pseudomonas aeruginosa DXPS (PaDXPS) with IC₅₀ values of 0.52 μM, 2.1 μM, 2.4 μM, and 1.7 μM for wild-type (WT) EcDXPS, EcA426E, WT PaDXPS, and PaE431A, respectively .

HY-157840

Anti-infective agent 9	Parasite	Infection
Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC₅₀=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS) .

HY-134914

Fosmidomycin	Antibiotic Parasite	Infection
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .

HY-170783

DXR-IN-4	Parasite	Infection
DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC₅₀s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC₅₀ of 11 μM and 12 μM .

Cat. No.	Product Name	Type

HY-W415921

1-Deoxy-D-threo-pentulose	Carbohydrates
1-Deoxy-D-threo-pentulose is a derivative of D-xylulose, which has application activity in the study of mevalonate pathway. 1-Deoxy-D-threo-pentulose is widely used to explore the mechanism of cell metabolism. 1-Deoxy-D-threo-pentulose has important experimental value in biochemical research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010256

*D-Xylulose*	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-xylulose is a precursor of the pentiol D-arabitol.

HY-134914

Fosmidomycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Parasite
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .

Cat. No.	Compare	Product Name	Species	Source

HY-P71457

	Dxr/DXP reductoisomerase Protein, E.coli (Myc, His) dxr; ispC; yaeM; b0173; JW01681-deoxy-D-Xylulose 5-phosphate reductoisomerase; DXP reductoisomerase; EC 1.1.1.267; 1-deoxyXylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase	E.coli	E. coli
	Dxr/DXP Reductoisomerase is pivotal in isoprenoid biosynthesis, catalyzing the rearrangement and reduction of DXP to yield MEP. This step is critical in forming isoprenoid precursors, essential for cellular processes and metabolite synthesis. The enzyme's activity emphasizes its significance in regulating isoprenoid biosynthesis and cellular functions. Dxr/DXP reductoisomerase Protein, E.coli (Myc, His) is the recombinant E. coli-derived Dxr/DXP reductoisomerase protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W010256S3

D-Xylulose-13C5
D-Xylulose-13C5 is ¹³C labeled D-Xylulose. D-xylulose is the precursor of arabinitol .

HY-W010256S

D-Xylulose-1-13C
D-Xylulose-1- ¹³C is the ¹³C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].

HY-W010256S1

D-Xylulose-2-13C
D-Xylulose-2- ¹³C is the ¹³C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].

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D-Xylulose

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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