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Results for "

DGAT1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (16) BCRP (2) Biochemical Assay Reagents (1) OAT (2) Parasite (1)
By Research Areas:	Infection (3) Metabolic Disease (17)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50670

DGAT-1 inhibitor 2 2 Publications Verification	Acyltransferase	Metabolic Disease
DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.

HY-10038

A 922500 Maximum Cited Publications 16 Publications Verification DGAT-1 inhibitor 4a	Acyltransferase	Metabolic Disease
A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of 9 and 22 nM against human and mouse DGAT-1, respectively.

HY-16434

DGAT1-IN-3	Acyltransferase	Metabolic Disease
DGAT1-IN-3 is a potent, selective and orally bioavailable inhibitor of *DGAT-1, with IC₅₀s of 38 nM for human DGAT-1* and 120 nM for rat *DGAT-1. DGAT1*-IN-3 could be used to research of obesity, dyslipidemia, and metabolic syndrome .

HY-12425

DGAT1-IN-1 1 Publications Verification	Acyltransferase	Metabolic Disease
DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

HY-15197

ABT-046	Acyltransferase	Metabolic Disease
ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of both 8 nM against human and mouse DGAT-1 .

HY-50861

AZD3988	Acyltransferase	Metabolic Disease
AZD3988 is an orally active diacylglycerol acyl transferase-1 (DGAT-1) inhibitor. AZD3988 has excellent DGAT-1 (human) potency with an IC₅₀ value of 0. 6 nM. AZD3988 can be used for the research of metabolic diseases such as diabetes, obesity .

HY-141572

1,2-Dioleoyl-sn-glycerol sn-1,2-Dioleoylglycerol	Biochemical Assay Reagents	Others
ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

HY-136707

DGAT-1 inhibitor 3	Acyltransferase	Metabolic Disease
DGAT-1 inhibitor 3 (compound 10) is a potent *DGAT-1* inhibitor with an IC₅₀ value of 0.038 µM. DGAT-1 inhibitor 3 has the potential for the research of obesity and diabetes .

HY-16266

JNJ-DGAT1-A	Acyltransferase	Metabolic Disease
JNJ-DGAT1-A is a selective *DGAT1* inhibitor. JNJ-DGAT1-A inhibits DGAT1 activity and TG synthesis .

HY-112851

Diacylglycerol acyltransferase inhibitor-1	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase *(DGAT1)* inhibitor.

HY-15497

AZD7687 1 Publications Verification	Acyltransferase	Metabolic Disease
AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC₅₀ of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research .

HY-N9153A

Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether	Others	Metabolic Disease
Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether is a *DGAT1* inhibitor with an IC₅₀ of 92.7 μM and can be extracted from Eleutherococcus senticosus. Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether can be utilized in research related to type II diabetes and obesity .

HY-13009

PF-04620110 4 Publications Verification	Acyltransferase	Metabolic Disease
PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC₅₀ of 19 nM .

HY-111417

GSK2973980A	Acyltransferase	Metabolic Disease
GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC₅₀ of 3 nM.

HY-N7281

Aphadilactone C	Acyltransferase Parasite	Infection
Aphadilactone C is a potent and selective *DGAT-1* inhibitor with an IC₅₀ of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC₅₀ value of 170 nM .

HY-32219

T863 5+ Cited Publications	Acyltransferase	Metabolic Disease
T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC₅₀ of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells .

HY-16278

Pradigastat 2 Publications Verification LCQ-908	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-16278A

Pradigastat sodium LCQ 908 sodium	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-118386

H2-005	Others	Metabolic Disease
H2-005 is a compound that selectively inhibits diacylglycerol acyltransferase 2 (DGAT2) and has the activity to inhibit triacylglycerol synthesis in hepatocytes and preadipocytes. H2-005 significantly reduces triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. H2-005 exhibits specific inhibitory activity in DGAT2-overexpressing HEK293 cells. H2-005 almost completely inhibits lipid droplet formation in 3T3-L1 cells when co-treated with a DGAT1 inhibitor. H2-005 will contribute to DGAT2-related lipid metabolism research and the development of drugs to inhibit metabolic diseases .

Cat. No.	Product Name	Type

HY-141572

1,2-Dioleoyl-sn-glycerol sn-1,2-Dioleoylglycerol	Drug Delivery
ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

1,2-Dioleoyl-sn-glycerol

sn-1,2-Dioleoylglycerol

Drug Delivery

ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether	Structural Classification Monophenols Source classification Phenols Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Others
Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether is a *DGAT1* inhibitor with an IC₅₀ of 92.7 μM and can be extracted from Eleutherococcus senticosus. Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether can be utilized in research related to type II diabetes and obesity .

Aphadilactone C	Structural Classification Terpenoids Source classification Diterpenoids Plants Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker	Acyltransferase Parasite
Aphadilactone C is a potent and selective *DGAT-1* inhibitor with an IC₅₀ of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC₅₀ value of 170 nM .

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