Search Result

Search Result

Results for "

DNA-PKcs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA-PK (8) Apoptosis (2) ATM/ATR (2) Autophagy (1) HDAC (1) IGF-1R (1) Insulin Receptor (1) mTOR (1) PI3K (1) PROTACs (1)
By Research Areas:	Cancer (12) Endocrinology (1)

12

Inhibitors & Agonists

5

Antibodies

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis PKC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

STL127705 4 Publications Verification	DNA-PK Apoptosis	Cancer
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC₅₀ of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis .

DA-143	mTOR PI3K	Cancer
DA-143 is a selective *DNA-PKcs* inhibitor (IC₅₀: 2.5 nM), and the IC₅₀s for mTOR, PI3KΔ, and ATM are 280 nM, 106 nM and 6,594 nM respectively. DA-143 blocks phosphorylation of DNA-PKcs substrates. DA-143 sensitizes cancer cells to Doxorubicin (HY-15142) .

DNA-PK-IN-4	DNA-PK	Cancer
DNA-PK-IN-4 is a potent inhibitor of DNA-PK. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) .

DNA-PK-IN-6	DNA-PK	Cancer
DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) .

DNA-PK-IN-5	DNA-PK	Cancer
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) .

Abd110	PROTACs ATM/ATR	Cancer
Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs .

TMU 35435	HDAC Autophagy	Cancer
TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC .

NU5455	DNA-PK	Cancer
NU5455 is a potent, selective, and orally active inhibitor of *DNA-PKcs*. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect .

XRD-0394	ATM/ATR DNA-PK	Cancer
XRD-0394 is a potent and specific dual inhibitor of ATM and *DNA-PKcs* with oral activity. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. In addition, XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro .

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .

DNA-PK-IN-2	DNA-PK	Cancer
DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .

AG1024 5+ Cited Publications Tyrphostin AG 1024	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of IR (IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity .

Cat. No.	Compare	Product Name	Application	Reactivity

	DNA PKcs Antibody (YA957) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	DNA PKcs Antibody (YA957) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA957), targeting DNA PKcs, with a predicted molecular weight of 469 kDa (observed band size: 450 kDa). DNA PKcs Antibody (YA957) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

	DNA PKcs Antibody (YA959) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	DNA PKcs Antibody (YA959) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA959), targeting DNA PKcs, with a predicted molecular weight of 469 kDa (observed band size: 469 kDa). DNA PKcs Antibody (YA959) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

	DNA-PKcs/PRKDC Antibody	WB, ICC/IF, IHC-P	Human
	DNA-PKcs/PRKDC Antibody is a non-conjugated and Mouse origined monoclonal antibody about 469 kDa, targeting to DNA-PKcs/PRKDC. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human.

	DNA PKcs Antibody (YA958) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, ICC/IF, IP	Human
	DNA PKcs Antibody (YA958) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA958), targeting DNA PKcs, with a predicted molecular weight of 469 kDa (observed band size: 450 kDa). DNA PKcs Antibody (YA958) can be used for WB, ICC/IF, IP experiment in human background.

	*Phospho-DNA PKcs* (Ser2056) Antibody (YA1823)** PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-P, ICC/IF	Human
	Phospho-DNA PKcs (Ser2056) Antibody (YA1823) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1823), targeting Phospho-DNA PKcs (Ser2056), with a predicted molecular weight of 469 kDa (observed band size: 469 kDa). Phospho-DNA PKcs (Ser2056) Antibody (YA1823) can be used for WB, IHC-P, ICC/IF experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

MedChemExpress Magic Cece

MedChemExpress: Contact Us; About Us; Headquarters; Distributors; Statement on False Report; Careers

Customer Support: Technical Support; Service; Ordering Information; Easy Return; Shipping Rates & Policies; Intellectual Property Promise

Resources: Free Sample; Resources; Molarity Calculator; Dilution Calculator; Terms & Conditions; Reconstitution Calculator; Specific Activity Calculator

Subscribe to our E-newsletter

Name
Email *

	Sorry, but the email address you supplied was invalid.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.

Copyright © 2013-2024 MedChemExpress. All Rights Reserved.: Site Map Privacy Policy

Join with us