2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR DNA-PK
  4. XRD-0394

XRD-0394 is a potent and specific dual inhibitor of ATM and DNA-PKcs with oral activity. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. In addition, XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro.

For research use only. We do not sell to patients.

XRD-0394 Chemical Structure

XRD-0394 Chemical Structure

CAS No. : 2595308-10-2

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XRD-0394 Related Antibodies

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Description

XRD-0394 is a potent and specific dual inhibitor of ATM and DNA-PKcs with oral activity. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. In addition, XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro[1].

Molecular Weight

527.61

Formula

C26H30FN5O4S
CAS No.
SMILES

O=C(C12CCC2)N(C)C3=C1C4=CC(C5=CN=C(OCCNC(C)C)C(NS(C)(=O)=O)=C5)=C(F)C=C4N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XRD-0394 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XRD-03942595308-10-2XRD0394XRD 0394ATM/ATRDNA-PKAtaxia telangiectasia mutatedATM and RAD3 relatedDNA-dependent protein kinasetargeted deliverycancertumor cell killingInhibitorinhibitorinhibit

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