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Results for "

FTase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Farnesyl Transferase (19) Amino Acid Derivatives (1) Apoptosis (6) Autophagy (2) GGTase (3) Microtubule/Tubulin (1) Parasite (1) Ras (6) Reference Standards (1)
By Research Areas:	Cancer (21) Infection (10) Inflammation/Immunology (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Farnesyl Transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10502

Tipifarnib Maximum Cited Publications 11 Publications Verification IND 58359; R115777	Farnesyl Transferase	Infection Cancer
Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC₅₀ of 0.86 nM. Antineoplastic activity and antiparasitic activity .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-10502A

Tipifarnib (S enantiomer) IND-58359 S enantiomer; (S)-(-)-R-115777	Farnesyl Transferase	Cancer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC₅₀ of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

HY-128044

Ftase inhibitor I B581	Farnesyl Transferase	Cancer
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras) .

HY-149015

FTase-IN-1	Farnesyl Transferase	Cancer
FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC₅₀ of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity .

HY-142655

Ftase inhibitor III	Farnesyl Transferase	Infection
Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen.

HY-19301

J 104871 J-104135	Farnesyl Transferase	Cancer
J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC₅₀ of 3.9 nM in the presence of farnesyl pyrophosphate (FPP) .

HY-120271

GGTI-297	Ras	Cancer
GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC₅₀ values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras .

HY-W022657

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC₅₀s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-124205

Pepticinnamin E	Farnesyl Transferase	Infection Cancer
Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC₅₀=42 µM). Pepticinnamin E can be used in cancer and malaria research .

HY-15872A

FTI-277 hydrochloride 5 Publications Verification	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

HY-15872

FTI-277	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

HY-110038

FTI-277 TFA	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 TFA is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 TFA can inhibit hepatitis delta virus (HDV) infection.

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-123242A

FTI-2153 TFA	Farnesyl Transferase	Cancer
FTI-2153 TFA is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 TFA is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-128041

alpha-Hydroxy farnesyl phosphonic acid Hydroxyfarnesyl phosphate	Farnesyl Transferase	Others
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.

HY-15136

Lonafarnib 5+ Cited Publications Sch66336	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-16229A

GGTI-2154 hydrochloride	Apoptosis GGTase	Cancer
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC₅₀ of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer .

HY-16229

GGTI-2154	Apoptosis	Cancer
GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC₅₀ of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 can be used for the research of cancer .

HY-15136B

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Infection Cancer
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-16231

GGTI-2418	Apoptosis	Cancer
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC₅₀s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .

HY-15136R

Lonafarnib (Standard) Sch66336 (Standard)	Reference Standards Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-12369

GGTI-2133 1 Publications Verification	GGTase	Inflammation/Immunology
GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma .

HY-12369A

GGTI-2133 TFA	GGTase	Inflammation/Immunology
GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma .

HY-118916A

FTI-2148 diTFA	Farnesyl Transferase	Cancer
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-W022657

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .

Tectol	Infection Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701885

	FNTA Protein, Human FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human is the recombinant human-derived FNTA protein, expressed by E. coli , with tag free.

HY-P701886

	FNTA Protein, Human (His, StrepⅡ) FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human (His, Strep) is the recombinant human-derived FNTA protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

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HY-P83099

	FNTB Antibody (YA2844) FNTB; Protein farnesyltransferase subunit beta; FTase-beta; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta	WB, IP	Human
	FNTB Antibody (YA2844) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2844), targeting FNTB, with a predicted molecular weight of 49 kDa (observed band size: 49 kDa). FNTB Antibody (YA2844) can be used for WB, IP experiment in human background.

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FTase

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
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