GBA

By Targets:	Endogenous Metabolite (5) Glucosylceramide Synthase (GCS) (5) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Metabolic Disease (6) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101399

γ-Glu-Phe γ-Glutamylphenylalanine	Endogenous Metabolite	Others
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-101399A

γ-Glu-Phe TFA γ-Glutamylphenylalanine TFA	Endogenous Metabolite	Others
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-16743

Ibiglustat 3 Publications Verification Venglustat; SAR402671; GZ402671	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743B

Ibiglustat succinate 3 Publications Verification Venglustat succinate; SAR402671 succinate; GZ402671 succinate	Glucosylceramide Synthase (GCS)	Neurological Disease
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-RS05302

GBA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GBA2 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GBA2 Human Pre-designed siRNA Set A GBA2 Human Pre-designed siRNA Set A

HY-RS05301

GBA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GBA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GBA1 Human Pre-designed siRNA Set A GBA1 Human Pre-designed siRNA Set A

HY-RS05303

GBA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GBA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GBA3 Human Pre-designed siRNA Set A GBA3 Human Pre-designed siRNA Set A

HY-155411

HPSE1-IN-2	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-155410

HPSE1-IN-1	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-16743C

Ibiglustat hydrochloride Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743A

Ibiglustat (L-Malic acid) 3 Publications Verification Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-101399S

γ-Glu-(Phe-13C9,15N) γ-Glutamylphenylalanine-¹³C₉,¹⁵N	Isotope-Labeled Compounds	Others
γ-Glu-(Phe- ¹³C9, ¹⁵N) is the ¹³C and ¹⁵N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.

HY-101399R

γ-Glu-Phe (Standard)	Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

Cat. No.	Product Name	Target	Research Area

HY-101399

γ-Glu-Phe γ-Glutamylphenylalanine	Endogenous Metabolite	Others
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-101399A

γ-Glu-Phe TFA γ-Glutamylphenylalanine TFA	Endogenous Metabolite	Others
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-101399R

γ-Glu-Phe (Standard)	Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101399

γ-Glu-Phe γ-Glutamylphenylalanine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-101399A

γ-Glu-Phe TFA γ-Glutamylphenylalanine TFA	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-155411

HPSE1-IN-2	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-155410

HPSE1-IN-1	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-101399R

γ-Glu-Phe (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

Species:	Human (3) Mouse (1)
Tag:	His (3) GST (1)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75786

	GBA/Glucosylceramidase Protein, Human (HEK293, His) Lysosomal acid glucosylceramidase; Alglucerase; Beta-GC; SGTase; GC; GLUC	Human	HEK293
	GBA (glucosylceramidase) is a lysosomal enzyme that degrades lipids and aids in cell membrane turnover. It hydrolyzes glucosylceramide to form ceramide and glucose. GBA/Glucosylceramidase Protein, Human (HEK293, His) is the recombinant human-derived GBA/Glucosylceramidase protein, expressed by HEK293 , with C-His labeled tag.

HY-P703073

	GBA/Glucosylceramidase Protein, Mouse (HEK293, His) Acid beta-glucosidase; Beta-glucocerebrosidase; SGTase; Cholesteryl-beta-glucosidase	Mouse	HEK293
	GBA/glucosylceramidase protein catalyzes the hydrolysis of glucosylceramide/GlcCers into free ceramide and glucose within lysosomes. It plays a key role in lipid degradation and cell membrane turnover. GBA/Glucosylceramidase Protein, Mouse (HEK293, His) is the recombinant mouse-derived GBA/Glucosylceramidase protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P703794

	GBA/glucocerebrosidase Protein, Human (HEK293, His) Acid beta-glucosidase; Beta-glucocerebrosidase; SGTase; Cholesteryl-beta-glucosidase	Human	HEK293

HY-P71650

	*Cytosolic beta-Glucosidase/GBA3 Protein, Human (GST)* CBG; CBGL1; Cytosolic beta glucosidase ; Cytosolic beta glucosidase like protein 1; Cytosolic beta-glucosidase; Glucosidase beta acid 3; Klotho related protein ; KLRP	Human	E. coli
	Cytosolic β-glucosidase/GBA3 is a multifunctional neutral cytosolic β-glucosidase that displays broad substrate specificity, suggesting a possible involvement in glycosylceramide catabolism. Although it exhibits significant glucosylceramidase activity in vitro, its in vivo relevance is unclear. Cytosolic beta-Glucosidase/GBA3 Protein, Human (GST) is the recombinant human-derived Cytosolic beta-Glucosidase/GBA3 protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-101399S

γ-Glu-(Phe-13C9,15N)
γ-Glu-(Phe- ¹³C9, ¹⁵N) is the ¹³C and ¹⁵N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83512

	GBA Antibody (YA3257) Alglucerase; betaGC; GBA1; GCase; GCB; GLUC; Glucosylceramidase; Imiglucerase	WB, IHC-P	Human, Rat
	GBA Antibody (YA3257) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3257), targeting GBA, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). GBA Antibody (YA3257) can be used for WB, IHC-P experiment in human, rat background.

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Cat. No.	Product Name		Classification

HY-RS05302

GBA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GBA2 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05301

GBA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GBA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05303

GBA3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GBA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GBA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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GBA

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