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Isoforms Recommended:	HSP40

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Hsp40

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By Targets:	HSP (4) Parasite (1)
By Research Areas:	Cancer (3) Infection (1)

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Inhibitors & Agonists

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

KNK437 3 Publications Verification Heat Shock Protein Inhibitor I	HSP	Cancer
KNK437 is a *HSP* inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

MAL3-101	HSP	Cancer
MAL3-101 is a potent *HSP70* allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) .

ML346 5 Publications Verification	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

Malonganenone A	Parasite HSP	Infection
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

Cat. No.	Compare	Product Name	Species	Source

	HSP40/DNAJB1 Protein, Human (His) rHuDnaJ homolog subfamily B member 1/Hsp40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; Heat Shock 40 kDa Protein 1; Hsp40; Heat Shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HspF1	Human	E. coli
	HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag.

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	Hsp40 Antibody DNAJB1; DNAJ1; HDJ1; HspF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; Hsp40; Heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
	Hsp40 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 38 kDa, targeting to Hsp40. It can be used for WB assays with tag free, in the background of Human.

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