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Results for "

Htt

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Serotonin Transporter (1) Amyloid-β (1) Apoptosis (1) Atg8/LC3 (1) Caspase (1) CD47 (1) Huntingtin (8) P-glycoprotein (1) Raf (1) Small Interfering RNA (siRNA) (2) α-synuclein (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Neurological Disease (13)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (5) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Serotonin Transporter

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156650

Votoplam	Huntingtin	Neurological Disease
Votoplam is an *HTT* gene regulator with an IC₅₀ ≤ 0.1 μM. Votoplam can be used in the research of Huntington's disease .

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HttRx sodium	Huntingtin	Neurological Disease
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-132579

Tominersen RG6042; IONIS-HttRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-132593A

Rovanersen sodium WVE-120101 sodium	Huntingtin	Neurological Disease
Rovanersen sodium is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of *HTT* gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen sodium can be used for huntington’s disease research .

HY-143792

HTT-D3	P-glycoprotein	Neurological Disease
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research .

HY-RS18021

Htt Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Htt Mouse Pre-designed siRNA Set A contains three designed siRNAs for Htt gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Htt Mouse Pre-designed siRNA Set A Htt Mouse Pre-designed siRNA Set A

HY-RS06490

HTT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HTT Human Pre-designed siRNA Set A contains three designed siRNAs for HTT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HTT Human Pre-designed siRNA Set A HTT Human Pre-designed siRNA Set A

HY-P10822

ED11	Caspase	Neurological Disease
ED11 is a potent and selective caspase-6 inhibitor with an IC₅₀ of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD) .

HY-W792458

MADAM	Serotonin Transporter	Neurological Disease
MADAM exhibits high affinity and selectivity for *5-HTT* with a K_i value of 1.6 nM. MADAM has the potential to serve as a PET radiotracer for visualizing the serotonin transporter .

HY-132593

Rovanersen WVE-120101	Huntingtin	Neurological Disease
Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of *HTT* gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research .

HY-150236

FITC-labeled Tominersen sodium	Huntingtin	Neurological Disease
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-156103

mHTT-IN-2	Huntingtin	Neurological Disease
mHTT-IN-2 (compound 27) is a potent inhibitor (EC₅₀=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy .

HY-10542A

(Z)-GW 5074	Atg8/LC3 Raf	Neurological Disease
(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder .

HY-16009

Buntanetap (+)-Phenserine; ANVS401	α-synuclein	Neurological Disease Inflammation/Immunology
Buntanetap ((+)-Phenserine) is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .

HY-136780

SEN177	Amyloid-β Apoptosis CD47 Huntingtin	Neurological Disease Cancer
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The K_i of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC₅₀ is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases .

Cat. No.	Product Name	Type

HY-150236

FITC-labeled Tominersen sodium	Dyes
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

Cat. No.	Product Name	Target	Research Area

HY-P10822

ED11	Caspase	Neurological Disease
ED11 is a potent and selective caspase-6 inhibitor with an IC₅₀ of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD) .

Species:	Human (2)
Tag:	Tag Free (1) Strep (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P703209

	SERT Protein, Human (HEK293) Htt; SERT	Human	HEK293
	SERT Protein, Human (HEK293) is the recombinant human-derived SERT, expressed by HEK293 , with tag Free labeled tag. ,

HY-P703210

	SERT Protein, Human (HEK293, Strep) Htt; SERT	Human	HEK293
	SERT Protein, Human (HEK293, Strep) is the recombinant human-derived SERT, expressed by HEK293 , with Strep labeled tag. ,

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HY-P81893

	Serotonin Transporter Antibody (YA1638) SLC6A4; 5Htt; 5HT transporter; 5-Htt; 5-HttLPR; OCD1; SERT; Serotonin transporter; HSERT; SERT1	WB	Human, Mouse, Rat
	Serotonin Transporter Antibody (YA1638) is a non-conjugated IgG antibody, targeting Serotonin Transporter, with a predicted molecular weight of 70 kDa (observed band size: 70 kDa). Serotonin Transporter Antibody (YA1638) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HttRx sodium		Antisense Oligonucleotides
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-132579

Tominersen RG6042; IONIS-HttRx		Antisense Oligonucleotides
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-132593A

Rovanersen sodium WVE-120101 sodium		Antisense Oligonucleotides
Rovanersen sodium is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of *HTT* gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen sodium can be used for huntington’s disease research .

HY-150236

FITC-labeled Tominersen sodium		Antisense Oligonucleotides
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-RS18021

Htt Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Htt Mouse Pre-designed siRNA Set A contains three designed siRNAs for Htt gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06490

HTT Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
HTT Human Pre-designed siRNA Set A contains three designed siRNAs for HTT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-132593

Rovanersen WVE-120101		Antisense Oligonucleotides
Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of *HTT* gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research .

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