2. Neuronal Signaling Apoptosis Immunology/Inflammation
  3. Amyloid-β Apoptosis CD47 Huntingtin
  4. SEN177

SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The Ki of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC50 is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases.

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SEN177 Chemical Structure

SEN177 Chemical Structure

CAS No. : 2117405-13-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

SEN177 Related Antibodies

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Description

SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The Ki of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC50 is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases[1][2][3].

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
16.7 nM
Compound: 4; SEN177
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay
[PMID: 31411468]
In Vitro

SEN177 (0-50 μM; 0-96 h) effectively blocks the interaction between CD47 and SIRRPα in breast cancer cell line MDA-MB-468[2].
SEN177 (10 μM; 3 days) significantly enhances the ability of EGFR antibody to induce ADCP in esophageal squamous cell carcinoma (Kyse-30) and breast cancer cell line (MDA-MB-468)[2].
SEN177 (50 μM; 24 h) decreases mutant HTT aggregate ratio and apoptosis in HeLa cells expressing HTT (Q74)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SEN177 Related Antibodies
In Vivo

SEN177 (50 μM; Oral administration; Change every two days) has a protective effect in the Huntington Drosophila model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Drosophila expressing Httex1Q46 in the eye[3]
Dosage: 50 μM
Administration: Oral administration (p.o.); Change every two days
Result: Reduced the number of aggregates.
Rescued the number of visible rhabdomeres.
Prevented neurodegeneration.
Molecular Weight

338.38

Formula

C18H19FN6
CAS No.
Appearance

Solid

Color

Brown to gray

SMILES

CN1C(C2CCN(C3=NC=CC=C3C4=CC=C(F)N=C4)CC2)=NN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (92.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9553 mL 14.7763 mL 29.5526 mL
5 mM 0.5911 mL 2.9553 mL 5.9105 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 97.10%

SDS (479 KB)

COA (254 KB) HNMR (249 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9553 mL 14.7763 mL 29.5526 mL 73.8814 mL
5 mM 0.5911 mL 2.9553 mL 5.9105 mL 14.7763 mL
10 mM 0.2955 mL 1.4776 mL 2.9553 mL 7.3881 mL
15 mM 0.1970 mL 0.9851 mL 1.9702 mL 4.9254 mL
20 mM 0.1478 mL 0.7388 mL 1.4776 mL 3.6941 mL
25 mM 0.1182 mL 0.5911 mL 1.1821 mL 2.9553 mL
30 mM 0.0985 mL 0.4925 mL 0.9851 mL 2.4627 mL
40 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8470 mL
50 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4776 mL
60 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2314 mL
80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
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SEN177 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEN1772117405-13-5SEN 177SEN-177Amyloid-βApoptosisCD47Huntingtinβ-amyloid peptideAβAbetaCluster of Differentiation 47MER6OA3glutaminyl cyclaseHuntington’s diseasesquamous cell carcinoma cellsbreast cancer cellsInhibitorinhibitorinhibit

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