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Hybrids

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79

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2

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9

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1

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11

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107987
    CXCR7 modulator 1

    		CXCR Endocrinology
    CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM .
    CXCR7 modulator 1
  • HY-114669
    Polyoxin C

    		Others Others
    Polyoxin C, the hybrid compound of nucleosides and R-amino acids, is important as the C-terminal amino acid component of Nikkomycin .
    Polyoxin C
  • HY-151935
    Antileishmanial agent-13

    		Parasite Infection
    Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively .
    Antileishmanial agent-13
  • HY-P35433
    Tifuvirtide

    T-1249

    		 HIV Inflammation/Immunology
    Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .
    Tifuvirtide
  • HY-144332
    PHD2/HDACs-IN-1

    		HDAC HIF/HIF Prolyl-Hydroxylase Cancer
    PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI) .
    PHD2/HDACs-IN-1
  • HY-145294
    ROCK2-IN-5

    		ROCK Neurological Disease
    ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .
    ROCK2-IN-5
  • HY-P5204
    Enterocin Hybrid 1

    K1-EJ hybrid

    		 Bacterial Infection
    Enterocin Hybrid 1 is a antibacterial agent, a antibacterial composition. Enterocin Hybrid 1 inhibits Vancomycin (HY-B0671)-resistant E. faecium, Staphylococcus haemoliticus .
    Enterocin Hybrid 1
  • HY-118295
    Pyrimidine-indole hybrid

    		Endogenous Metabolite Cancer
    Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics .
    Pyrimidine-indole hybrid
  • HY-18003
    Oleanolic acid derivative 2

    		Others Inflammation/Immunology
    Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.
    Oleanolic acid derivative 2
  • HY-18002
    Oleanolic acid derivative 1

    		Others Inflammation/Immunology
    Oleanolic acid derivative 1 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.
    Oleanolic acid derivative 1
  • HY-144255
    Antibacterial agent 70

    		ROS Kinase Inflammation/Immunology
    Antibacterial agent 70 is a new dihydropyrimidinone imidazole hybrid antibacterial agent, and its < b > MIC < / b > value is 0.5 μg/mL
    Antibacterial agent 70
  • HY-N7370
    Hybridaphniphylline B

    		Others Others
    Hybridaphniphylline B is a Daphniphyllum alkaloid and iridoid hybrid. Hybridaphniphylline B can be isolated from stems and leaves of Daphniphyllum longacemosum .
    Hybridaphniphylline B
  • HY-N9511
    Jacobine N-oxide

    		Others Others
    Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .
    Jacobine N-oxide
  • HY-E70135
    Endo-β-N-acetylglucosaminidase F1

    Endo F1

    		 Others Metabolic Disease
    Endo-β-N-acetylglucosaminidase F1 (Endo F1) cleaves Asparagine-linked high mannose and some hybrid oligosaccharides .
    Endo-β-N-acetylglucosaminidase F1
  • HY-117688
    WJ35435

    		HDAC Topoisomerase Apoptosis Cancer
    WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer .
    WJ35435
  • HY-P5768
    WSHPQFEKWSHPQFEK

    		Biochemical Assay Reagents Others
    WSHPQFEKWSHPQFEK is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. WSHPQFEKWSHPQFEK can be used to construct DNA-protein hybrids .
    WSHPQFEKWSHPQFEK
  • HY-125732
    Decarestrictine D

    		Others Infection
    Decarestrictine D exhibits inhibitory activity against cholesterol levels. Decarestrictine D is utilized as receptor for glycosylation reactions to synthesize novel hybrid antibiotics .
    Decarestrictine D
  • HY-150553
    COX-2-IN-28

    		COX Inflammation/Immunology
    COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .
    COX-2-IN-28
  • HY-120190
    Citreoindole

    		Others Infection
    Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.
    Citreoindole
  • HY-P5768A
    WSHPQFEKWSHPQFEK TFA

    		Biochemical Assay Reagents Cancer
    WSHPQFEKWSHPQFEK TFA is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. WSHPQFEKWSHPQFEK TFA can be used to construct DNA-protein hybrids .
    WSHPQFEKWSHPQFEK TFA
  • HY-163451
    Apoptosis inducer 17

    		Apoptosis Cancer
    Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells .
    Apoptosis inducer 17
  • HY-117429
    Se-Aspirin

    Selenium-acetylsalicylic acid

    		 NF-κB Inflammation/Immunology
    Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells .
    Se-Aspirin
  • HY-15035
    S-Diclofenac

    ACS 15; ATB-337

    		 COX Inflammation/Immunology
    S-Diclofenac is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis .
    S-Diclofenac
  • HY-119673
    Lincophenicol

    		Others Others
    Lincophenicol is a hybrid antibiotic that has the activity of inhibiting the puromycin reaction catalyzed by Escherichia coli ribosomal peptidyl transferase and also inhibits the binding of specific compounds to the Escherichia coli ribosome.
    Lincophenicol
  • HY-N7093
    Furaneol

    Strawberry furanone

    		 Others Others
    Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
    Furaneol
  • HY-P3383
    Peceleganan

    PL-5

    		 Bacterial Infection
    Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection .
    Peceleganan
  • HY-P3383A
    Peceleganan acetate

    PL-5 acetate

    		 Bacterial Infection
    Peceleganan (PL-5) acetate is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan acetate inhibits wound infection .
    Peceleganan acetate
  • HY-107164
    Thiomarinol A

    4-Hydroxythiomarinol C

    		 Antibiotic Bacterial Infection
    Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Ki app value of 19 nM .
    Thiomarinol A
  • HY-161340
    Anti-melanoma agent 2

    		Apoptosis Cancer
    Anti-melanoma agent 2 (Compound IId) is a steroid hybrid that effectively induces endoplasmic reticulum stress (ERS) and causes apoptosis. Anti-melanoma agent 2 shows anti-melanoma effects .
    Anti-melanoma agent 2
  • HY-162691
    DEP-5

    		Others Others
    DEP-5 is an inhibitor of acetohydroxyacid synthase (AHAS) with an inhibition constant of 39.4 μM. DEP-5 is a diphenyl ether-pyrimidine hybrid with herbicidal activity against the Leptochloa chinensis(L.) Nees .
    DEP-5
  • HY-P5552
    Melimine

    		Bacterial Parasite Fungal Infection
    Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa .
    Melimine
  • HY-114857
    Clofencet

    SC1158; SQ 1

    		 Others Others
    Clofencet (SC1158) is a wheat hybridizing agent, that produces hybrid wheat seeds through inhibition of pollen development in wheat without affecting female fertility. Clofencet improves the wheat’s vigor and its resistance to pests .
    Clofencet
  • HY-N11880
    2-O-Sinapoyl makisterone A

    		COX Cancer
    2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .
    2-O-Sinapoyl makisterone A
  • HY-W089777
    3-Glycidyloxypropyltrimethoxysilane

    GPTMS

    		 Biochemical Assay Reagents Others
    3-Glycidyloxypropyltrimethoxysilane (GPTMS) is the silicon source for the preparation of inorganic–organic hybrid polymers, which is used for hard coatings of organic polymers, contact lens materials in the optical industry, electronics, membranes, sensors, nanoimprinting, wave guides, and biology .
    3-Glycidyloxypropyltrimethoxysilane
  • HY-P99645
    Goflikicept

    RPH 104

    		 Interleukin Related Cardiovascular Disease Inflammation/Immunology
    Goflikicept (RPH 104) is a hybrid protein that selectively binds and inactivates both circulating IL-1ß and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) .
    Goflikicept
  • HY-147748
    COX-2-IN-17

    		COX Inflammation/Immunology
    COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .
    COX-2-IN-17
  • HY-19738
    NQTrp

    		Tau Protein Neurological Disease
    NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( 41GCWMLY 46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .
    NQTrp
  • HY-N7093R
    Furaneol (Standard)

    		Others Others
    Furaneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
    Furaneol (Standard)
  • HY-146174
    KCa1.1 channel activator-2

    		Potassium Channel Cardiovascular Disease
    KCa1.1 channel activator-2 (compound 3F), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel stimulator. KCa1.1 channel activator-2 exhibits potent myorelaxant activity .
    KCa1.1 channel activator-2
  • HY-16532
    Zoptarelin doxorubicin

    AEZS-108; AN-152

    		 GnRH Receptor Cancer
    Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .
    Zoptarelin doxorubicin
  • HY-162170
    Anti-inflammatory agent 72

    		NF-κB Keap1-Nrf2 p38 MAPK Inflammation/Immunology
    Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting NF-κB p65/iNOS and MAPKs signaling pathways .
    Anti-inflammatory agent 72
  • HY-128346
    PQM130

    		Amyloid-β Neurological Disease
    PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development .
    PQM130
  • HY-115970
    Tubulin inhibitor 21

    		Microtubule/Tubulin Cancer
    Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells .
    Tubulin inhibitor 21
  • HY-156188
    AChE-IN-41

    		Others Others
    AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .
    AChE-IN-41
  • HY-101359
    TPMPA

    		GABA Receptor Neurological Disease
    TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells .
    TPMPA
  • HY-W598230A
    m-PEG-NH2 hydrochloride (MW 2000)

    		Biochemical Assay Reagents Others
    m-PEG-NH2 (hydrochloride) (MW 2000) is a barrier permeation compound involved in the preparation of hybrid gels with adsorption and size exclusion chromatography (AdSEC) properties. m-PEG-NH2 helps AdSEC gels separate from complex biological mixtures such as blood, urine, sweat, and tears.
    m-PEG-NH2 hydrochloride (MW 2000)
  • HY-131678
    Palmitoyl serotonin

    PA-5HT

    		 Others Neurological Disease
    Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD) .
    Palmitoyl serotonin
  • HY-145908
    Antitumor agent-49

    		Others Cancer
    Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro .
    Antitumor agent-49
  • HY-W012998S1
    2,3-Pentanedione-13C2

    		Isotope-Labeled Compounds Others
    2,3-Pentanedione- 13C2 is 13C labeled Furaneol (HY-N7093). Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
    2,3-Pentanedione-13C2
  • HY-163899
    (+)-Crinatusin A1

    		Phosphatase Metabolic Disease
    (+)-Crinatusin A1 (Compound (+)- 4) is a chalcone-monoterpene hybrid, which can be isolated from Cleistocalyx operculatus. (+)-Crinatusin A1 is an inhibitor for protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.9 μM. (+)-Crinatusin A1 exhibits potential as an antidiabetic agent .
    (+)-Crinatusin A1

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