2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Topoisomerase Apoptosis
  4. WJ35435

WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer.

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WJ35435 Chemical Structure

WJ35435 Chemical Structure

CAS No. : 1620054-84-3

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WJ35435 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Topoisomerase Topo I Topo II

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Description

WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer[1].

Molecular Weight

351.40

Formula

C20H21N3O3
CAS No.
SMILES

O=C(C1=CC=CC2=CC3=C(N=C21)C=CC=C3)NCCCCCC(NO)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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WJ35435 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WJ354351620054-84-3WJ 35435WJ-35435HDACTopoisomeraseApoptosisHistone deacetylasesanticancer hybridtopoisomerase IDNA repair capabilitycell cycle arrestapoptosishistone H3 acetylationphosphorylationα-tubulin acetylationγ-H2AX formationcancerInhibitorinhibitorinhibit

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