Search Result
Results for "
ICaL
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
4
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-124020
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Biochemical Assay Reagents
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Others
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β-pBrPh-Glc is a small-molecule ice recrystallization inhibitor. β-pBrPh-Glc can control the rate and extent of intracellular ice recrystallization in the nuclei over a broad range of subzero temperatures. β-pBrPh-Glc is an important tool to improve the recovery and function of cryopreserved cells and tissues .
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- HY-112226
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Caspase
Drug Metabolite
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Inflammation/Immunology
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VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively .
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- HY-19676
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VX-740; HMR 3480
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Caspase
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Inflammation/Immunology
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Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment .
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- HY-112226R
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Reference Standards
Caspase
Drug Metabolite
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Inflammation/Immunology
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VRT-043198 (Standard) is the analytical standard of VRT-043198. This product is intended for research and analytical applications. VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].
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- HY-N15142
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Others
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Others
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Furcellaran is an anionic sulfated polysaccharide obtained from red algae. Furcellaran inhibits ice recrystallization as effectively as κ-Carrageenan (HY-138962). Furcellaran is promising for research of edible film production .
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- HY-151871
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Dipeptidyl Peptidase
HIV
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Infection
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ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs .
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- HY-156202
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Histone Demethylase
PD-1/PD-L1
Apoptosis
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Cancer
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Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC50 value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis .
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- HY-P2628
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Fluorescent Dye
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Others
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Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
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- HY-RS06518
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BRCC1; NARG2
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Small Interfering RNA (siRNA)
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Others
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ICE2 Human Pre-designed siRNA Set A contains three designed siRNAs for ICE2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ICE2 Human Pre-designed siRNA Set A
ICE2 Human Pre-designed siRNA Set A
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- HY-RS06517
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KIAA0947
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Small Interfering RNA (siRNA)
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Others
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ICE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ICE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ICE1 Human Pre-designed siRNA Set A
ICE1 Human Pre-designed siRNA Set A
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- HY-P2630
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Interleukin Related
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Inflammation/Immunology
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Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .
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- HY-N14670
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- HY-N14672
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- HY-P5890
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- HY-108163A
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Calcium Channel
Potassium Channel
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Neurological Disease
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SB-237376 is a blocker of potassium and calcium channels. SB-237376 inhibits the rapidly activating delayed rectifier potassium current I(Kr) (IC50: 0.42 μM) and blocks the L-type calcium current I(Ca,L) at high concentrations .
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- HY-W650842
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Caspase
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Cancer
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Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
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- HY-N2005
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- HY-120019A
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L-709049 acetate
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Interleukin Related
Caspase
Apoptosis
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Inflammation/Immunology
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Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .
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- HY-W012998
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Biochemical Assay Reagents
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Neurological Disease
Inflammation/Immunology
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2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-120019
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L-709049
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Interleukin Related
Apoptosis
Caspase
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Inflammation/Immunology
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Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
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- HY-W007355
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3-Methylindole; 3-Methyl-1H-indole
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Aryl Hydrocarbon Receptor
p38 MAPK
Endogenous Metabolite
Apoptosis
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Others
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Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
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- HY-16990
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Caspase-1 Inhibitor II
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Caspase
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Inflammation/Immunology
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Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
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- HY-W015487
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Ethyl 3-oxohexanoate
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Biochemical Assay Reagents
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Others
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Ethyl butyrylacetate is an organic compound belonging to the class of esters. Synthesized by the reaction of ethyl acetate, butyric acid and acetic anhydride. Ethyl butyrylacetate has a fruity aroma and is commonly used as a flavoring agent in various food and beverages such as candies, ice cream and soft drinks. It is also used as a fragrance ingredient in perfumes and personal care products. In addition to its use in the food and fragrance industries, Ethyl butyrylacetate is also used in industrial settings, such as in the production of solvents.
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- HY-W007355R
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3-Methylindole (Standard); 3-Methyl-1H-indole (Standard)
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Reference Standards
Aryl Hydrocarbon Receptor
p38 MAPK
Endogenous Metabolite
Apoptosis
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Others
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Skatole (Standard) is the analytical standard of Skatole. This product is intended for research and analytical applications. Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
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- HY-W012998S2
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Isotope-Labeled Compounds
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Others
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2,3-Pentanedione-d3 is deuterated labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-13205
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Belnacasan
Maximum Cited Publications
124 Publications Verification
VX-765
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Caspase
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Inflammation/Immunology
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Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
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- HY-W012998S
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Isotope-Labeled Compounds
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Others
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2,3-Pentanedione-d5 is the deuterium labeled 2,3-Pentanedione . 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-N6745S
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Na+/K+ ATPase
Apoptosis
Isotope-Labeled Compounds
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Infection
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Citreoviridin- 13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-W012998R
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Reference Standards
Biochemical Assay Reagents
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Neurological Disease
Inflammation/Immunology
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2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-13205R
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Caspase
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Inflammation/Immunology
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Belnacasan (Standard) is the analytical standard of Belnacasan. This product is intended for research and analytical applications. Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
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- HY-W715850
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Ethyl 3-oxohexanoate-d5
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Isotope-Labeled Compounds
Biochemical Assay Reagents
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Others
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Ethyl butyrylacetate-d5 (Ethyl 3-oxohexanoate-d5) is the deuterium labeled Ethyl butyrylacetate (HY-W015487). Ethyl butyrylacetate is an organic compound belonging to the class of esters. Synthesized by the reaction of ethyl acetate, butyric acid and acetic anhydride. Ethyl butyrylacetate has a fruity aroma and is commonly used as a flavoring agent in various food and beverages such as candies, ice cream and soft drinks. It is also used as a fragrance ingredient in perfumes and personal care products. In addition to its use in the food and fragrance industries, Ethyl butyrylacetate is also used in industrial settings, such as in the production of solvents.
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- HY-108163
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Calcium Channel
Potassium Channel
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Cardiovascular Disease
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SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I(Kr) (IC50 is 0.42 μM), and at high concentrations, it blocks the L-type calcium current I(Ca,L). In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 µM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases .
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HY-L022M
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3,089 compounds
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New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.
MCE owns a unique collection of 3,089 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.
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| Cat. No. |
Product Name |
Type |
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- HY-P2628
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Fluorescent Dyes/Probes
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Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
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| Cat. No. |
Product Name |
Type |
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- HY-W015487
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Ethyl 3-oxohexanoate
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Drug Delivery
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Ethyl butyrylacetate is an organic compound belonging to the class of esters. Synthesized by the reaction of ethyl acetate, butyric acid and acetic anhydride. Ethyl butyrylacetate has a fruity aroma and is commonly used as a flavoring agent in various food and beverages such as candies, ice cream and soft drinks. It is also used as a fragrance ingredient in perfumes and personal care products. In addition to its use in the food and fragrance industries, Ethyl butyrylacetate is also used in industrial settings, such as in the production of solvents.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P3832
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Peptides
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Others
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Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei .
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- HY-120019
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L-709049
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Interleukin Related
Apoptosis
Caspase
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Inflammation/Immunology
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Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
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- HY-P2628
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Fluorescent Dye
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Others
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Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
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- HY-P2630
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Interleukin Related
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Inflammation/Immunology
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Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .
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- HY-P5890
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- HY-W650842
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Caspase
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Cancer
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Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N2005
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- HY-W012998
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Structural Classification
Microorganisms
other families
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Other Diseases
Plants
Disease Research Fields
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Biochemical Assay Reagents
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2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-W007355
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- HY-W007355R
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- HY-W012998R
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Structural Classification
Microorganisms
other families
Ketones, Aldehydes, Acids
Source classification
Plants
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Reference Standards
Biochemical Assay Reagents
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2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-N15142
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- HY-N14670
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- HY-N14672
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-W012998S2
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2,3-Pentanedione-d3 is deuterated labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-W012998S
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2,3-Pentanedione-d5 is the deuterium labeled 2,3-Pentanedione . 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-N6745S
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Citreoviridin- 13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-W715850
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Ethyl butyrylacetate-d5 (Ethyl 3-oxohexanoate-d5) is the deuterium labeled Ethyl butyrylacetate (HY-W015487). Ethyl butyrylacetate is an organic compound belonging to the class of esters. Synthesized by the reaction of ethyl acetate, butyric acid and acetic anhydride. Ethyl butyrylacetate has a fruity aroma and is commonly used as a flavoring agent in various food and beverages such as candies, ice cream and soft drinks. It is also used as a fragrance ingredient in perfumes and personal care products. In addition to its use in the food and fragrance industries, Ethyl butyrylacetate is also used in industrial settings, such as in the production of solvents.
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| Cat. No. |
Product Name |
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Classification |
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- HY-RS06518
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BRCC1; NARG2
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siRNAs
Human Pre-designed siRNA Sets
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ICE2 Human Pre-designed siRNA Set A contains three designed siRNAs for ICE2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS06517
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KIAA0947
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siRNAs
Human Pre-designed siRNA Sets
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ICE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ICE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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