IKB

By Targets:	Apoptosis (2) Btk (3) Caspase (1) EGFR (1) FLT3 (1) GABA Receptor (1) IAP (1) IKK (4) IRAK (1) PARP (1) Phosphatase (1) PI3K (1) PPAR (1) PROTACs (2)
By Research Areas:	Cancer (7) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19362

AZD3264 2 Publications Verification	IKK	Inflammation/Immunology
AZD3264 is a selective IkB-kinase IKK2 inhibitor.

HY-19383

Ertiprotafib PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of *PTP1B, IkB* kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀** of ~1 μM for PPARα/PPARβ.

HY-12461

WS6	PI3K EGFR GABA Receptor FLT3 IKK	Neurological Disease Metabolic Disease Inflammation/Immunology
WS6 is an *IkB* kinase and EBP1 inhibitor, with IC₅₀ values of 0.24 nM, 0.21 nM, and 40.48 nM in MV4-11, MOLM13, and K562 cells, respectively. WS6 promotes the proliferation of alpha and beta cells in the pancreas, has antioxidant and anti-inflammatory activities, and can alleviate depression like behavior in rats ^[1][2][4].

HY-153188

JNJ-1013	Apoptosis IRAK	Cancer
JNJ-1013 is a potent and selective IRAK1 degrader with an IC₅₀s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) .

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-112557

PROTAC TBK1 degrader-2	PROTACs IKK	Cancer
PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC₅₀=15 nM; K_d=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC₅₀=8.7 nM), with low selectivity over TBK1 (IC₅₀=1.3 nM) .

HY-17600

Acalabrutinib 20+ Cited Publications ACP-196	Btk	Cancer
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N12836

Peniditerpenoid A	Others	Metabolic Disease
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis .

HY-147906

Anticancer agent 71	Apoptosis PARP	Cancer
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity .

HY-17600R

Acalabrutinib (Standard)	Btk	Cancer
Acalabrutinib (Standard) is the analytical standard of Acalabrutinib. This product is intended for research and analytical applications. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17600S

Acalabrutinib-d4 ACP-196-d₄	Btk	Cancer
Acalabrutinib-d₄ is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12836

Peniditerpenoid A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76986

	IKB beta/NFKBIB Protein, Human (His) NF-kappa-B inhibitor beta; NF-kappa-BIB; TRIP-9; IKBB	Human	E. coli
	IKB beta/NFKBIB protein effectively inhibits NF-kappa-B and prevents NF-kappa-B activation by forming a cytoplasmic complex. After cell stimulation, the non-phosphorylated form is resynthesized, binds to NF-kappa-B, aids nuclear transport, and protects NF-kappa-B from NFKBIA-dependent inactivation. IKB beta/NFKBIB Protein, Human (His) is the recombinant human-derived IKB beta/NFKBIB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701230

	*NFKBIE/IKB* epsilon Protein, Human (His)** C20orf18; HOIL-1; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; UBCE7IP3; XAP3; XAP4; ZRANB4	Human	E. coli
	NFKBIE/IKB epsilon Protein crucially inhibits NF-kappa-B by forming a cytoplasmic complex, preventing its DNA-binding activity. It targets specific complexes involving p50-p65, p50-c-Rel, and interacts with subunits RELA, REL, NFKB1 (p50), and NFKB2 (p52). NFKBIE/IKB epsilon plays a pivotal role in regulating NF-kappa-B signaling, controlling nuclear translocation and transcriptional activities. NFKBIE/IKB epsilon Protein, Human (His) is the recombinant human-derived NFKBIE/IKB epsilon protein, expressed by E. coli , with N-10*His labeled tag. The total length of NFKBIE/IKB epsilon Protein, Human (His) is 500 a.a., with molecular weight of ~57 kDa.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-17600S

Acalabrutinib-d4
Acalabrutinib-d₄ is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80718

	IKB alpha Antibody NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IHC-P, IP	Human, Mouse, Rat
	IKB alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to IKB alpha. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80466

	*Phospho-IKB* alpha (Ser32) Antibody (YA183)**	WB, ICC/IF, IP	Human, Mouse
	Phospho-IKB alpha (Ser32) Antibody (YA183) is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha(S32). It can be used for WB,ICC,IP assays with tag free, in the background of Human, Mouse.

HY-P80827

	*Phospho-IKB* alpha (Ser36) Antibody** NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB	Human, Mouse
	Phospho-IKB alpha (Ser36) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser36). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80826

	*Phospho-IKB* alpha (Ser32) Antibody (YA185)** NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IP	Human, Mouse
	Phospho-IKB alpha (Ser32) Antibody (YA185) is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser32). It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P83267

	IKB epsilon Antibody (YA3012) NFKBIE; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IKB-E; IKB-epsilon; IkappaBepsilon	WB, IP	Human
	IKB epsilon Antibody (YA3012) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3012), targeting IKB epsilon, with a predicted molecular weight of 53 kDa (observed band size: 48 kDa). IKB epsilon Antibody (YA3012) can be used for WB, IP experiment in human background.

HY-P83343

	IKB beta Antibody (YA3088) NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IKB-B; IKB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9	WB, IHC-P, IP	Human, Mouse
	IKB beta Antibody (YA3088) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3088), targeting IKB beta, with a predicted molecular weight of 38 kDa (observed band size: 48 kDa). IKB beta Antibody (YA3088) can be used for WB, IHC-P, IP experiment in human, mouse background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Name
Email *

	Sorry, but the email address you supplied was invalid.

IKB

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products