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Results for "

IRS-1

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Peptides

4

Natural
Products

2

Recombinant Proteins

1

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115461
    MID-1

    		Insulin Receptor Metabolic Disease
    MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake [1].
    MID-1
  • HY-145935
    NT219

    		Insulin Receptor STAT Cancer
    NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases [1].
    NT219
  • HY-N3628
    Coronarin A

    		mTOR Ribosomal S6 Kinase (RSK) Metabolic Disease Inflammation/Immunology
    Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research [1].
    Coronarin A
  • HY-P5433F
    IRS-1 Peptide, FAM labeled

    		Insulin Receptor Others
    IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)
    IRS-1 Peptide, FAM labeled
  • HY-RS06917
    IRS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    IRS1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IRS1 Human Pre-designed siRNA Set A
    IRS1 Human Pre-designed siRNA Set A
  • HY-153479A
    Aganirsen sodium

    		Insulin Receptor Inflammation/Immunology
    Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).
    Aganirsen sodium
  • HY-153479
    Aganirsen

    		Insulin Receptor Inflammation/Immunology
    Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).
    Aganirsen
  • HY-107758
    Y-29794 oxalate

    		Prolyl Endopeptidase (PREP) Cancer
    Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) [1] .
    Y-29794 oxalate
  • HY-N3542
    Carpachromene

    		Glycosidase Cancer
    Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway [1].
    Carpachromene
  • HY-15113
    Y-29794

    		Prolyl Endopeptidase (PREP) Neurological Disease Cancer
    Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) [1] .
    Y-29794
  • HY-15113A
    Y-29794 tosylate

    		Prolyl Endopeptidase (PREP) Neurological Disease Cancer
    Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) [1] .
    Y-29794 tosylate
  • HY-161321
    PTP1B-IN-24

    		Phosphatase Insulin Receptor Akt Metabolic Disease
    PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT [1].
    PTP1B-IN-24
  • HY-162499
    MY17

    		Phosphatase Metabolic Disease
    MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50=0.41±0.05 μM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with PTP1B, MY17 can inhibit the activity of PTP1B, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes [1].
    MY17
  • HY-N0479
    Licarin B
    1 Publications Verification

    (-)-Licarin B

    		 PPAR GLUT Metabolic Disease
    Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway [1] .
    Licarin B
  • HY-100037
    NT157
    1 Publications Verification

    Tyrphostin NT157

    		 Insulin Receptor STAT Endocrinology Cancer
    NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway [1] .
    NT157
  • HY-158381
    PROTAC PTP1B degrader 1

    		PROTACs Phosphatase Metabolic Disease
    PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC50 values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand) [1].
    PROTAC PTP1B degrader 1
  • HY-124097
    HNMPA-(AM)3

    		Insulin Receptor Metabolic Disease
    HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively) [1] .
    HNMPA-(AM)3
  • HY-N0322
    Cholesterol
    Maximum Cited Publications
    41 Publications Verification

    		 Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial Metabolic Disease Cancer
    Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins [1] . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
    Cholesterol

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