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Results for "

KYSE520

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161952
    JAB-3312

    		SHP2 Cancer
    JAB-3312 is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. JAB-3312 has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model .
    JAB-3312
  • HY-145703
    SHP2 protein degrader-2

    		SHP2 PROTACs Phosphatase Cancer
    SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells .
    SHP2 protein degrader-2
  • HY-145162
    SHP2-D26
    1 Publications Verification

    		 SHP2 PROTACs Phosphatase Cancer
    SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent .
    SHP2-D26
  • HY-114397
    SHP394
    1 Publications Verification

    		 SHP2 Phosphatase Cancer
    SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM .
    SHP394
  • HY-172454
    SHP2-IN-36

    		SHP2 Cancer
    SHP2-IN-36 (Compound B8) is an allosteric inhibitor of SHP2, with an IC50 value of 9.0 nM. In addition, its IC50 for p-ERK is 40 nM. SHP2-IN-36 also exhibited significant antitumor activity in the KYSE520 xenograft mouse model. SHP2-IN-36 can be used for research in the field of anti-tumor .
    SHP2-IN-36

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