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Results for "

LRP6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (4) Autophagy (3) Bacterial (3) Mitophagy (1) Parasite (3) Porcupine (1) Small Interfering RNA (siRNA) (1) Wnt (8) β-catenin (5)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (1) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HLY78 5+ Cited Publications	Wnt β-catenin Apoptosis	Cardiovascular Disease Neurological Disease Cancer
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research .

Gallocyanine chloride	Wnt	Neurological Disease
Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting *DKK1/LRP6* interaction. Its association with LRP6 is weak (IC₅₀ of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies .

Salinomycin sodium salt Maximum Cited Publications 27 Publications Verification Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

Salinomycin Maximum Cited Publications 27 Publications Verification Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells .

IWP-O1	Porcupine Wnt	Cancer
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC₅₀ of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells .

LRP6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LRP6 Human Pre-designed siRNA Set A contains three designed siRNAs for LRP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LRP6 Human Pre-designed siRNA Set A LRP6 Human Pre-designed siRNA Set A

Salinomycin sodium salt (Standard)	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (sodium salt) (Standard) is the analytical standard of Salinomycin (sodium salt). This product is intended for research and analytical applications. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

C1s Enzyme masp-2, c1 esterase, c1-esterase	Wnt	Cardiovascular Disease Inflammation/Immunology
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity .

Wnt/β-catenin-IN-2	Wnt β-catenin	Cancer
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a Wnt/β-catenin signaling pathway inhibitor, with IC₅₀ and K_D values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .

Cat. No.	Compare	Product Name	Species	Source

	LRP-6 Protein, Human (HEK293, mFc) LRP-6; DCAD2; FLJ90062; FLJ90421	Human	HEK293
	LRP-6 protein is a key component of the Wnt-Fzd-LRP5-LRP6 complex, a component of β-catenin signaling, and is essential for bone formation. LRP-6 acts as a cell surface co-receptor and coordinates the formation of signalosomes by clustering receptor-ligand complexes. LRP-6 Protein, Human (HEK293, mFc) is the recombinant human-derived LRP-6 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of LRP-6 Protein, Human (HEK293, mFc) is 611 a.a., with molecular weight of 100-120 kDa.

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	LRP6 Antibody	WB, IHC-P	Human
	LRP6 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 180 kDa, targeting to LRP6. It can be used for WB,IHC-P assays with tag free, in the background of Human.

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LRP6 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LRP6 Human Pre-designed siRNA Set A contains three designed siRNAs for LRP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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