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M.tuberculosis

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By Targets:	Akt (1) Antibiotic (17) Antifolate (1) Autophagy (3) Bacterial (83) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (4) Endogenous Metabolite (1) Fungal (8) Isotope-Labeled Compounds (3) MMP (1) Monoamine Oxidase (1) Parasite (2) Potassium Channel (1) PROTACs (2) Proton Pump (2) TGF-beta/Smad (2) Thymidylate Synthase (5)
By Research Areas:	Cancer (6) Infection (91) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124781

ML406	Bacterial Antibiotic	Infection
ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .

HY-124814

C215	Bacterial	Infection
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC₉₀ of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .

HY-162142

BB2-50F	Bacterial	Infection
BB2-50F is a potent and multi-targeting bioenergetic bactericidal inhibitor of *M. tuberculosis* and can sterilizes replicating and non-replicating *M. tuberculosis. BB2-50F inhibits succinate oxidation, decreases the activity of the tricarboxylic acid (TCA) cycle, and results in succinate secretion from M. tuberculosis*.

HY-147017

GSK2556286 GSK286	Bacterial	Infection Inflammation/Immunology
GSK2556286 (GSK286) is an orally active inhibitor of M. tuberculosis. GSK2556286 inhibits growth within human macrophages (IC50 = 0.07 μM). GSK2556286 is effective against both multidrug-resistant (MDR) or extensively drug-resistant (XDR) and agent-sensitive (DS) M. tuberculosis.

HY-100725

BM212 3 Publications Verification	Bacterial	Infection
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .

HY-109587A

BM635 hydrochloride	Bacterial	Infection
BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC₅₀ of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635 .

HY-109587B

BM635 mesylate	Bacterial	Infection
BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC₅₀ of 0.6 μM against M. tuberculosis H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635 .

HY-146104

Antimycobacterial agent-1	Bacterial	Infection
Antimycobacterial agent-1 (compound 33) has selectively antimycobacterial activity against *Mycobacterium tuberculosis* (M. tuberculosis) H37Ra with a MIC** value of 1 μg/ml. Antimycobacterial agent-1 has relatively low cytotoxicity in normal cells (Vero cells IC₅₀ = 143.2 μg/ml) .

HY-136348

ML338	Bacterial	Infection
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis* bacilli* and is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis* bacilli* in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy .

HY-146699

MtTMPK-IN-5	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-5 (compound 17) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM). MtTMPK-IN-5 can be used for researching tuberculosis .

HY-146555

Antitubercular agent-14	Bacterial	Infection
Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .

HY-108941

Salicyl-AMS	Bacterial	Infection
Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit *M. tuberculosis* growth in vitro under iron-limited conditions.

HY-139618

Dup-721	Bacterial Antibiotic	Infection
DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis .

HY-146055

Antituberculosis agent-1	Bacterial	Infection
Antituberculosis agent-1 (Compound 8a) is an antituberculosis agent with an MIC of 3.84 µg/mL against M. tuberculosis H₃₇R_v .

HY-N2033

Chebulinic acid 2 Publications Verification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-13579

BTZ043 3 Publications Verification	Bacterial Antibiotic	Infection
BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

HY-153572

Homo-BacPROTAC7	PROTACs Bacterial	Infection
Homo-BacPROTAC7 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

HY-153571

Homo-BacPROTAC6	PROTACs Bacterial	Infection
Homo-BacPROTAC6 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

HY-156414

DHFR-IN-11	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC₅₀ values 5.70 μM .

HY-N12600

Thiolopyrrolone A	Bacterial	Infection
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-116693

DprE1-IN-12	Bacterial	Infection
DprE1-IN-12 (compound 377790) is a covalent and DprE1 inhibitors and shows great activity against M. tuberculosis with an IC₅₀ of 0.5 μM .

HY-B0271

Pyrazinamide 2 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-109587

BM635	Bacterial	Infection
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

HY-112702

CRS400393	Bacterial	Infection
CRS400393 is a potent antimycobacterial agent, with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively .

HY-146700

MtTMPK-IN-6	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-6 (compound 1) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 29 μM. MtTMPK-IN-6 can be used for researching tuberculosis .

HY-14990

Sudoterb LL 3858	Bacterial	Infection
Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent .

HY-14990A

Sudoterb hydrochloride LL 3858 hydrochloride	Bacterial	Infection
Sudoterb (LL 3858) hydrochloride is an orally active anti-Tuberculosis agent .

HY-139596

Polyketide synthase 13-IN-3	Others	Infection Inflammation/Immunology
Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv .

HY-134648

Ganfeborole GSK656 free base; GSK3036656 free base; GSK070 free base	Bacterial	Infection
Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis .

HY-156412

DHFR-IN-10	Bacterial	Infection
DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC₅₀ of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency .

HY-146119

Antitubercular agent-24	Bacterial	Infection
Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC₅₀ of 0.83 μM and an intracellular IC₅₀ of 0.17 μM against M. tuberculosis H37Rv .

HY-147661

DHFR-IN-2	Antifolate	Infection
DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC₅₀ of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research .

HY-155395

DDAN-MT	Others	Infection
DDAN-MT is an enzymatic activated near-infrared fluorescent probe. DDAN-MT can be used for rapid, highly selective, and real-time monitoring of endogenous MtMET-AP1 activity in M. tuberculosis .

HY-45854

GWP-042 1 Publications Verification	Bacterial	Infection
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC₅₀ of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo .

HY-139654

α/β-Hydrolase-IN-1	Others	Infection
α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis* H37Ra*, respectively.

HY-N2876

Anisofolin A	Parasite Bacterial	Infection
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-146107

Antitubercular agent-23	Bacterial Fungal	Infection
Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-146106

Antitubercular agent-22	Bacterial Fungal	Infection
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-163033

Antitubercular agent-42	Bacterial	Infection
Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC₉₀ = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .

HY-N2033R

Chebulinic acid (Standard)	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) .

HY-151205

Antituberculosis agent-3	Bacterial	Infection Inflammation/Immunology
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .

HY-151339

Antitubercular agent-31	Bacterial	Infection
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC₅₀ of 1.1 μM .

HY-151614

Anti-infective agent 7	Bacterial	Infection
Anti-infective agent 7 is a potent anti-infectious agent. Anti-infective agent 7 has anti-infection activity against P. falciparum (IC₅₀=2.5 μM) and M. tuberculosis (MIC=9 μM) .

HY-163625

Mtb-IN-7	Monoamine Oxidase Bacterial	Infection
Mtb-IN-7 (compoun R7) is a MAO-A/MAO-B inhibitor with the IC₅₀ values over 40 μM. Mtb-IN-7 shows antimycobacterial activity against M. tuberculosis H37Rv with the MIC of 2.01 μM .

HY-B0271R

Pyrazinamide (Standard)	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-146120

Antitubercular agent-25	Bacterial	Infection
Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC₅₀ of 0.42 μM and an intracellular IC₅₀ of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .

HY-146374

Antibacterial agent 96	Bacterial	Infection
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells .

HY-151514

Antituberculosis agent-5	Bacterial	Infection
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC₅₀ value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .

HY-147818

DNA Gyrase-IN-2	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2033

Chebulinic acid 2 Publications Verification	Infection Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B0271

Pyrazinamide 2 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-16566A

Kanamycin sulfate 10+ Cited Publications Kanamycin A sulfate	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields	Bacterial Antibiotic
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-N8060A

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-N12600

Thiolopyrrolone A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Bacterial
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-N2876

Anisofolin A	Structural Classification Monophenols Flavonoids Flavones Labiatae Source classification Phenols Plants Artemisia persica Boiss.	Parasite Bacterial
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-N2033R

Chebulinic acid (Standard)	Structural Classification Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B0271R

Pyrazinamide (Standard)	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-N11048

Amycolatopsin A	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-N3612

Communic acid (+)-Communic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-B1906

Streptomycin Maximum Cited Publications 25 Publications Verification Agrept; Agrimycin; Streptomycin A	Microorganisms Source classification	Antibiotic Bacterial
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

Cat. No.	Product Name	Chemical Structure

HY-B0271S1

Pyrazinamide-13C,15N
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-10844S

Pretomanid-d4
Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL[1][2].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

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M.tuberculosis

Inhibitors & Agonists

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Isotope-Labeled Compounds

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